Linked Life Data

14610904

Source:http://linkedlifedata.com/resource/pubmed/id/14610904

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2003-11-12
pubmed:abstractText
Determinants of the host (quality and quantity of immune effectors, underlying disease, age), of the graft (organ type, HLA-mismatching, injury, permissiveness for virus infection) and of the virus (genus, organ tropism, fitness, antiviral resistance) define the risk of viral infection, morbidity and mortality in organ transplantation. This "menage-à-trois" of host, graft and virus is influenced by dose- or magnitude-dependent factors denoted modulators such as type and dose of immunosuppression, the degree of local and systemic inflammatory patterns well as use of immunoglobulins or antivirals. The most advanced concepts have been established for infections with cytomegalovirus (CMV). Three elements have been driving this progress: 1. Clinical-virological definitions of infection and disease; 2. quantitative viral assays in clinically relevant turn-around time; 3. effective antiviral agents. Further impact may be come from characterising the specific cellular immunity. The broader availability of quantitative assays based on real-time PCR can be expected to improve the diagnosis of "new" viruses of relevance in transplantation such as Epstein-Barr virus, polyomavirus BK, and viruses targeting the respiratory tract.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0040-5930
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
641-9
pubmed:dateRevised
2008-2-12
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
[Viral infections after transplantation].
pubmed:affiliation
Abteilung für Infektiologie am Kantonsspital Basel und Transplantations-Virologie am Institut für Medizinische Mikrobiologie, Universität Basel. hans.hirsch@unibas.ch
pubmed:publicationType
Journal Article, English Abstract