Linked Life Data

14581485

Source:http://linkedlifedata.com/resource/pubmed/id/14581485

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2004-1-5
pubmed:abstractText
Central and peripheral mammalian circadian clocks regulate a variety of behavioral and physiological processes through the rhythmic transcription of hundreds of clock-controlled genes. The circadian expression of many transcriptional regulators suggests that a major part of this circadian gene network is indirectly regulated by clock genes. Here we show that the basic helix-loop-helix transcriptional repressor Stra13 is rhythmically expressed in mouse peripheral organs. The circadian transcription of Stra13 is mediated by a response element recognized by the CLOCK-BMAL1 heterodimer and located in the proximal promoter region. CLOCK-BMAL1-dependent activation of Stra13 is strongly repressed by CRY1 and also by STRA13 itself. To determine putative Stra13 output genes, we performed microarray analyses of differential gene expression in the liver between wild type and Stra13-/- mice and identified 42 target genes including a subset of 20 previously known as clock-controlled genes. Importantly, we demonstrate that circadian gene expression of the serum protein insulin-like growth factor-binding protein 1 and of the NKG2D receptor ligand retinoic acid early transcript was suppressed in Stra13-/- mice. These biochemical and genetic data establish a role for the basic helix-loop-helix repressor STRA13 as a circadian output regulator in the periphery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
279
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1141-50
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:14581485-Animals, pubmed-meshheading:14581485-Basic Helix-Loop-Helix Transcription Factors, pubmed-meshheading:14581485-Blotting, Western, pubmed-meshheading:14581485-COS Cells, pubmed-meshheading:14581485-Circadian Rhythm, pubmed-meshheading:14581485-Dimerization, pubmed-meshheading:14581485-Homeodomain Proteins, pubmed-meshheading:14581485-Insulin-Like Growth Factor Binding Protein 1, pubmed-meshheading:14581485-Ligands, pubmed-meshheading:14581485-Liver, pubmed-meshheading:14581485-Mice, pubmed-meshheading:14581485-Mice, Inbred C57BL, pubmed-meshheading:14581485-NIH 3T3 Cells, pubmed-meshheading:14581485-NK Cell Lectin-Like Receptor Subfamily K, pubmed-meshheading:14581485-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:14581485-Oscillometry, pubmed-meshheading:14581485-Promoter Regions, Genetic, pubmed-meshheading:14581485-Protein Structure, Tertiary, pubmed-meshheading:14581485-Receptors, Immunologic, pubmed-meshheading:14581485-Receptors, Natural Killer Cell, pubmed-meshheading:14581485-Ribonucleases, pubmed-meshheading:14581485-Time Factors, pubmed-meshheading:14581485-Transcription, Genetic
pubmed:year
2004
pubmed:articleTitle
The transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs.
pubmed:affiliation
Université de Nice-Sophia Antipolis, CNRS UMR 6078, La Darse, 06230 Villefranche/mer, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't