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rdf:type |
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lifeskim:mentions |
umls-concept:C0014230,
umls-concept:C0017262,
umls-concept:C0032207,
umls-concept:C0140145,
umls-concept:C0178874,
umls-concept:C0185117,
umls-concept:C0677886,
umls-concept:C0683598,
umls-concept:C1332102,
umls-concept:C1707520,
umls-concept:C2603343,
umls-concept:C2911684
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pubmed:issue |
13
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pubmed:dateCreated |
2003-10-28
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pubmed:abstractText |
A crucial step in the DNA base excision repair pathway involves the cleavage of an apurinic/apyrimidinic site by an apurinic/apyrimidinic endonuclease (APE). The major APE in mammalian cells is APE/ref-1, a multifunctional enzyme that acts not only as a DNA repair enzyme but as a redox-modifying factor for a variety of transcription factors. The purpose of this study is to determine whether APE/ref-1 expression differs with ovarian cancer progression and metastasis and in platinum-resistant disease.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4689-94
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14581338-Antibodies, Monoclonal,
pubmed-meshheading:14581338-Cell Nucleus,
pubmed-meshheading:14581338-DNA Repair,
pubmed-meshheading:14581338-DNA-(Apurinic or Apyrimidinic Site) Lyase,
pubmed-meshheading:14581338-Disease Progression,
pubmed-meshheading:14581338-Drug Resistance, Neoplasm,
pubmed-meshheading:14581338-Female,
pubmed-meshheading:14581338-Humans,
pubmed-meshheading:14581338-Immunohistochemistry,
pubmed-meshheading:14581338-Neoplasm Metastasis,
pubmed-meshheading:14581338-Neoplasms, Glandular and Epithelial,
pubmed-meshheading:14581338-Ovarian Neoplasms,
pubmed-meshheading:14581338-Platinum Compounds,
pubmed-meshheading:14581338-Tumor Markers, Biological
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pubmed:year |
2003
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pubmed:articleTitle |
Studies of apurinic/apyrimidinic endonuclease/ref-1 expression in epithelial ovarian cancer: correlations with tumor progression and platinum resistance.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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