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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5645
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pubmed:dateCreated |
2003-10-24
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pubmed:abstractText |
Spontaneous resolution of hepatitis C virus (HCV) infection in humans usually affords long-term immunity to persistent viremia and associated liver diseases. Here, we report that memory CD4+ Tcells are essential for this protection. Antibody-mediated depletion of CD4+ Tcells before reinfection of two immune chimpanzees resulted in persistent, low-level viremia despite functional intra-hepatic memory CD8+ Tcell responses. Incomplete control of HCV replication by memory CD8+ Tcells in the absence of adequate CD4+ Tcell help was associated with emergence of viral escape mutations in class I major histocompatibility complex-restricted epitopes and failure to resolve HCV infection.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
24
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pubmed:volume |
302
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
659-62
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14576438-Amino Acid Sequence,
pubmed-meshheading:14576438-Amino Acid Substitution,
pubmed-meshheading:14576438-Animals,
pubmed-meshheading:14576438-Antigen Presentation,
pubmed-meshheading:14576438-Antigens, Viral,
pubmed-meshheading:14576438-CD4-Positive T-Lymphocytes,
pubmed-meshheading:14576438-CD8-Positive T-Lymphocytes,
pubmed-meshheading:14576438-Epitopes,
pubmed-meshheading:14576438-Evolution, Molecular,
pubmed-meshheading:14576438-Hepacivirus,
pubmed-meshheading:14576438-Hepatitis C,
pubmed-meshheading:14576438-Immunologic Memory,
pubmed-meshheading:14576438-Liver,
pubmed-meshheading:14576438-Major Histocompatibility Complex,
pubmed-meshheading:14576438-Molecular Sequence Data,
pubmed-meshheading:14576438-Mutation,
pubmed-meshheading:14576438-Pan troglodytes,
pubmed-meshheading:14576438-T-Lymphocyte Subsets,
pubmed-meshheading:14576438-Time Factors,
pubmed-meshheading:14576438-Viral Core Proteins,
pubmed-meshheading:14576438-Viral Nonstructural Proteins,
pubmed-meshheading:14576438-Viremia,
pubmed-meshheading:14576438-Virus Replication
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pubmed:year |
2003
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pubmed:articleTitle |
HCV persistence and immune evasion in the absence of memory T cell help.
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pubmed:affiliation |
Center for the Study of Hepatitis C, Rockefeller University, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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