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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2003-10-23
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pubmed:abstractText |
Olopatadine hydrochloride is an H1-receptor-blocker but has other anti-allergic pharmacological potencies. We investigated whether olopatadine inhibits murine contact hypersensitivity, focussing on its modulatory action on epidermal Langerhans cells serving as antigen-presenting cells. While BALB/c mice were sensitized and challenged epicutaneously with hapten, they were administered intraperitoneally with olopatadine. Olopatadine at 1 or 0.2 mg/kg of weight significantly suppressed the sensitivity when injected at least once before sensitization or challenge. In olopatadine-injected mice, the ability of Langerhans cells to present hapten to primed T cells was reduced with decreased expression of MHC class II and co-stimulatory molecules. Langerhans cells exposed in vitro to 10(-5) or 10(-6) M olopatadine had less antigen-presenting activity than control, whereas neither T cell proliferation nor keratinocyte production of IL-1alpha and IP-10 was affected at these doses. These findings suggest that olopatadine downmodulates contact hypersensitivity at least partly by interfering with the antigen-presenting ability of Langerhans cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0008-8749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
224
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
47-54
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pubmed:dateRevised |
2010-7-29
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pubmed:meshHeading |
pubmed-meshheading:14572800-Animals,
pubmed-meshheading:14572800-Anti-Allergic Agents,
pubmed-meshheading:14572800-Antigen Presentation,
pubmed-meshheading:14572800-Antigens, Surface,
pubmed-meshheading:14572800-Cells, Cultured,
pubmed-meshheading:14572800-Chemokine CXCL10,
pubmed-meshheading:14572800-Dermatitis, Contact,
pubmed-meshheading:14572800-Dibenzoxepins,
pubmed-meshheading:14572800-Disease Models, Animal,
pubmed-meshheading:14572800-Dose-Response Relationship, Drug,
pubmed-meshheading:14572800-Down-Regulation,
pubmed-meshheading:14572800-Epidermis,
pubmed-meshheading:14572800-Female,
pubmed-meshheading:14572800-Haptens,
pubmed-meshheading:14572800-Histocompatibility Antigens Class II,
pubmed-meshheading:14572800-Interleukin-1,
pubmed-meshheading:14572800-Keratinocytes,
pubmed-meshheading:14572800-Langerhans Cells,
pubmed-meshheading:14572800-Mice,
pubmed-meshheading:14572800-Mice, Inbred BALB C,
pubmed-meshheading:14572800-T-Lymphocytes
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pubmed:year |
2003
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pubmed:articleTitle |
Anti-allergic drug olopatadine suppresses murine contact hypersensitivity and downmodulates antigen-presenting ability of epidermal Langerhans cells.
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pubmed:affiliation |
Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan. tokura@med.uoeh-u.ac.jp
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pubmed:publicationType |
Journal Article
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