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pubmed-article:14565386pubmed:abstractTextIn an effort to further improve the hybridisation potential of anhydro-hexitol nucleoside analogues, the 1'-methoxyl and 3'-methoxyl substituents were introduced and evaluated for their antisense potential. In view of the selectivity of pairing with RNA, especially the introduction of a 3'-O-alkyl moiety deserves further study.lld:pubmed
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pubmed-article:14565386pubmed:articleTitleMethylated hexitol nucleic acids, towards congeners with improved antisense potential.lld:pubmed
pubmed-article:14565386pubmed:affiliationLaboratory for Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium. arthur.vanaerschot@rega.kuleuven.ac.belld:pubmed
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