Linked Life Data

14561867

Source:http://linkedlifedata.com/resource/pubmed/id/14561867

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
28
pubmed:dateCreated
2003-10-16
pubmed:abstractText
What is the role of dopamine in natural rewards? A genetic mutant approach was taken to examine the consequences of elevated synaptic dopamine on (1) spontaneous food and water intake, (2) incentive motivation and learning to obtain a palatable sweet reward in a runway task, and (3) affective "liking" reactions elicited by the taste of sucrose. A dopamine transporter (DAT) knockdown mutation that preserves only 10% of normal DAT, and therefore causes mutant mice to have 70% elevated levels of synaptic dopamine, was used to identify dopamine effects on food intake and reward. We found that hyperdopaminergic DAT knockdown mutant mice have higher food and water intake. In a runway task, they demonstrated enhanced acquisition and greater incentive performance for a sweet reward. Hyperdopaminergic mutant mice leave the start box more quickly than wild-type mice, require fewer trials to learn, pause less often in the runway, resist distractions better, and proceed more directly to the goal. Those observations suggest that hyperdopaminergic mutant mice attribute greater incentive salience ("wanting") to a sweet reward in the runway test. But sucrose taste fails to elicit higher orofacial "liking" reactions from mutant mice in an affective taste reactivity test. These results indicate that chronically elevated extracellular dopamine facilitates "wanting" and learning of an incentive motivation task for a sweet reward, but elevated dopamine does not increase "liking" reactions to the hedonic impact of sweet tastes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9395-402
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:14561867-Animals, pubmed-meshheading:14561867-Appetitive Behavior, pubmed-meshheading:14561867-Behavior, Animal, pubmed-meshheading:14561867-Body Weight, pubmed-meshheading:14561867-Dopamine, pubmed-meshheading:14561867-Dopamine Plasma Membrane Transport Proteins, pubmed-meshheading:14561867-Drinking, pubmed-meshheading:14561867-Eating, pubmed-meshheading:14561867-Exploratory Behavior, pubmed-meshheading:14561867-Extracellular Fluid, pubmed-meshheading:14561867-Facial Expression, pubmed-meshheading:14561867-Learning, pubmed-meshheading:14561867-Male, pubmed-meshheading:14561867-Membrane Glycoproteins, pubmed-meshheading:14561867-Membrane Transport Proteins, pubmed-meshheading:14561867-Mice, pubmed-meshheading:14561867-Mice, Neurologic Mutants, pubmed-meshheading:14561867-Mutation, pubmed-meshheading:14561867-Nerve Tissue Proteins, pubmed-meshheading:14561867-Reward, pubmed-meshheading:14561867-Stimulation, Chemical, pubmed-meshheading:14561867-Sucrose, pubmed-meshheading:14561867-Synapses, pubmed-meshheading:14561867-Taste
pubmed:year
2003
pubmed:articleTitle
Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards.
pubmed:affiliation
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109-1109, USA. pesu@umich.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't