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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1992-12-31
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pubmed:abstractText |
Interactions between 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PnCDD) and 2,4,5,2',4',5'-hexachlorobiphenyl (HxCB) on hepatic retention of PnCDD and on cytochrome P450 related enzyme activities were studied in male C57BL/6J mice. Animals received 8 nmol PnCDD/kg orally, alone or in combination with 1-416 mumol HxCB/kg. Co-administration of HxCB did not alter the hepatic retention of PnCDD or the 7-ethoxyresorufin-O-deethylation (EROD) activity induced by PnCDD as observed after 1 week. A small antagonistic effect on total cytochrome P450 content and 7-pentoxyresorufin-O-depentylation (PROD) activity was observed at a dose of 8 nmol PnCDD/kg and 1 mumol HxCB/kg. Furthermore, a significant induction of PROD activity by PnCDD was found. This was not expected, since PROD activity is considered to be a specific marker for CYP2b related enzyme activity and this type of cytochrome P450 is not induced by polychlorinated dibenzo-p-dioxins such as PnCDD. It is concluded that, under these short-term experimental conditions, no toxicokinetic basis was found to explain the antagonistic effects on hepatic cytochrome P450 related activities observed in the present study or in other studies.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,2,3,7,8-pentachlorodibenzo-p-dioxi...,
http://linkedlifedata.com/resource/pubmed/chemical/2,4,5,2',4',5'-hexachlorobiphenyl,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP2B1,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Polychlorinated Biphenyls,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrachlorodibenzodioxin
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0300-483X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
21-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1455422-Animals,
pubmed-meshheading:1455422-Cytochrome P-450 CYP1A1,
pubmed-meshheading:1455422-Cytochrome P-450 CYP2B1,
pubmed-meshheading:1455422-Cytochrome P-450 Enzyme System,
pubmed-meshheading:1455422-Dose-Response Relationship, Drug,
pubmed-meshheading:1455422-Drug Interactions,
pubmed-meshheading:1455422-Enzyme Induction,
pubmed-meshheading:1455422-Isoenzymes,
pubmed-meshheading:1455422-Liver,
pubmed-meshheading:1455422-Male,
pubmed-meshheading:1455422-Mice,
pubmed-meshheading:1455422-Mice, Inbred C57BL,
pubmed-meshheading:1455422-Oxidoreductases,
pubmed-meshheading:1455422-Polychlorinated Biphenyls,
pubmed-meshheading:1455422-Tetrachlorodibenzodioxin
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pubmed:year |
1992
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pubmed:articleTitle |
Absence of interactions on hepatic retention and 7-ethoxyresorufin-O-deethylation activity after co-administration of 1,2,3,7,8-pentachlorodibenzo-p-dioxin and 2,4,5,2',4',5'-hexachlorobiphenyl.
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pubmed:affiliation |
Research Institute of Toxicology, University of Utrecht, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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