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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2003-10-10
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pubmed:abstractText |
We have modeled smallpox vaccination with Dryvax (Wyeth) in rhesus macaques that had depletion of CD4(+) T cells induced by infection with simian immunodeficiency virus or simian/human immunodeficiency virus. Smallpox vaccination induced significantly larger skin lesions in immunocompromised macaques than in healthy macaques. Unexpectedly, "progressive vaccinia" was infrequent. Vaccination of immunocompromised macaques with the genetically-engineered, replication-deficient poxvirus NYVAC, before or after retrovirus infection, was safe and lessened the severity of Dryvax-induced skin lesions. Neutralizing antibodies to vaccinia were induced by NYVAC, even in macaques with severe CD4(+) T cell depletion, and their titers inversely correlated with the time to complete resolution of the skin lesions. Together, these results provide the proof of concept, in macaque models that mirror human immunodeficiency virus type 1 infection, that a prime-boost approach with a highly attenuated poxvirus followed by Dryvax increases the safety of smallpox vaccination, and they highlight the importance of neutralizing antibodies in protection against virulent poxvirus.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1899
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pubmed:author |
pubmed-author:BelyakovIgor MIM,
pubmed-author:BerzofskyJay AJA,
pubmed-author:BrayMikeM,
pubmed-author:Edghill-SmithYvetteY,
pubmed-author:FranchiniGenoveffaG,
pubmed-author:GoldingHanaH,
pubmed-author:HirschVanessaV,
pubmed-author:KarpovaTatianaT,
pubmed-author:KingLisa RLR,
pubmed-author:LewisMark GMG,
pubmed-author:ManischewitzJodyJ,
pubmed-author:MarkhamPhilP,
pubmed-author:MartinDerrickD,
pubmed-author:McNallyJamesJ,
pubmed-author:MoniuszkoMarcinM,
pubmed-author:MossBernardB,
pubmed-author:NacsaJanosJ,
pubmed-author:ParrishJohnJ,
pubmed-author:SnodgrassSteven JSJ,
pubmed-author:SowersMarshaM,
pubmed-author:TartagliaJimJ,
pubmed-author:TryniszewskaElzbietaE,
pubmed-author:TsaiWen-PoWP,
pubmed-author:VenzonDavidD
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
188
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1181-91
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14551889-Animals,
pubmed-meshheading:14551889-Antibodies, Viral,
pubmed-meshheading:14551889-Disease Models, Animal,
pubmed-meshheading:14551889-HIV Infections,
pubmed-meshheading:14551889-HIV-1,
pubmed-meshheading:14551889-Humans,
pubmed-meshheading:14551889-Immunization Schedule,
pubmed-meshheading:14551889-Immunocompromised Host,
pubmed-meshheading:14551889-Macaca mulatta,
pubmed-meshheading:14551889-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:14551889-Simian immunodeficiency virus,
pubmed-meshheading:14551889-Skin,
pubmed-meshheading:14551889-Smallpox,
pubmed-meshheading:14551889-Smallpox Vaccine,
pubmed-meshheading:14551889-Vaccination,
pubmed-meshheading:14551889-Vaccines, Attenuated,
pubmed-meshheading:14551889-Vaccinia virus,
pubmed-meshheading:14551889-Viral Vaccines
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pubmed:year |
2003
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pubmed:articleTitle |
Modeling a safer smallpox vaccination regimen, for human immunodeficiency virus type 1-infected patients, in immunocompromised macaques.
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pubmed:affiliation |
Laboratory of Receptor Biology and Gene Expression, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-5055, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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