Linked Life Data

14550684

Source:http://linkedlifedata.com/resource/pubmed/id/14550684

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2003-10-10
pubmed:abstractText
Mice with a genetic disruption (knockout) of the multiple drug resistance (abcb1ab) gene were used to examine the effect of the absence of the drug-transporting P-glycoprotein (P-gp) at the blood-brain barrier on the uptake of the antidepressants venlafaxine, paroxetine, mirtazapine, and doxepin and its metabolites into the brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters, http://linkedlifedata.com/resource/pubmed/chemical/Antidepressive Agents, http://linkedlifedata.com/resource/pubmed/chemical/Cyclohexanols, http://linkedlifedata.com/resource/pubmed/chemical/Doxepin, http://linkedlifedata.com/resource/pubmed/chemical/Mianserin, http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoprotein, http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/P-glycoprotein 2, http://linkedlifedata.com/resource/pubmed/chemical/Paroxetine, http://linkedlifedata.com/resource/pubmed/chemical/mirtazapine, http://linkedlifedata.com/resource/pubmed/chemical/multidrug resistance protein 3, http://linkedlifedata.com/resource/pubmed/chemical/venlafaxine
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-3223
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
840-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:14550684-ATP-Binding Cassette Transporters, pubmed-meshheading:14550684-Animals, pubmed-meshheading:14550684-Antidepressive Agents, pubmed-meshheading:14550684-Blood-Brain Barrier, pubmed-meshheading:14550684-Brain, pubmed-meshheading:14550684-Chromatography, High Pressure Liquid, pubmed-meshheading:14550684-Cyclohexanols, pubmed-meshheading:14550684-Doxepin, pubmed-meshheading:14550684-Drug Resistance, Multiple, pubmed-meshheading:14550684-Gene Expression, pubmed-meshheading:14550684-Injections, Subcutaneous, pubmed-meshheading:14550684-Kidney, pubmed-meshheading:14550684-Liver, pubmed-meshheading:14550684-Male, pubmed-meshheading:14550684-Mianserin, pubmed-meshheading:14550684-Mice, pubmed-meshheading:14550684-Mice, Knockout, pubmed-meshheading:14550684-P-Glycoprotein, pubmed-meshheading:14550684-P-Glycoproteins, pubmed-meshheading:14550684-Paroxetine, pubmed-meshheading:14550684-Point Mutation, pubmed-meshheading:14550684-Spleen
pubmed:year
2003
pubmed:articleTitle
Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption.
pubmed:affiliation
Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D-80804 Munich, Germany.
pubmed:publicationType
Journal Article, Comparative Study