Source:http://linkedlifedata.com/resource/pubmed/id/14534738
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2003-10-9
|
| pubmed:abstractText |
In order to assess the effect of the DNA polymerase inhibitor aphidicolin on resistance to cytosine arabinoside, blast cells from 15 children with ALL and 9 with AML were exposed to a range of concentrations of ara-C +/- aphidicolin. Cell survival was measured using the MTT assay. Aphidicolin significantly increased sensitivity to ara-C in blast cells from both ALL (p=0.001) and AML (p<0.01). The median fold increase (sensitisation ratio) for ALL was 3.4 (range 1.2-13.6) compared to 12.4-fold (range 6.0-148) for AML blasts (p=0.005). There was a striking relationship between increasing ara-C resistance and increasing effect of aphidicolin in AML (p<0.001) but not ALL (p>0.05). These remarkable results suggest that aphidicolin should be considered for future clinical trials as a modulator of ara-C resistance, particularly in AML.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1021-335X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2027-31
|
| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:14534738-Aphidicolin,
pubmed-meshheading:14534738-Cell Survival,
pubmed-meshheading:14534738-Child,
pubmed-meshheading:14534738-Child, Preschool,
pubmed-meshheading:14534738-Clinical Trials as Topic,
pubmed-meshheading:14534738-Cytarabine,
pubmed-meshheading:14534738-DNA-Directed DNA Polymerase,
pubmed-meshheading:14534738-Dose-Response Relationship, Drug,
pubmed-meshheading:14534738-Drug Resistance, Neoplasm,
pubmed-meshheading:14534738-Drug Synergism,
pubmed-meshheading:14534738-Enzyme Inhibitors,
pubmed-meshheading:14534738-Female,
pubmed-meshheading:14534738-Humans,
pubmed-meshheading:14534738-Infant,
pubmed-meshheading:14534738-Leukemia, Myeloid, Acute,
pubmed-meshheading:14534738-Male,
pubmed-meshheading:14534738-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:14534738-Time Factors
|
| pubmed:articleTitle |
Aphidicolin decreases ex vivo resistance to cytosine arabinoside in childhood acute leukaemia.
|
| pubmed:affiliation |
Haematology Research, Pembury Hospital, Kent, TN2 4QJ, UK. jean@mackaysargent.fsnet.co.uk
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|