Linked Life Data

14530735

Source:http://linkedlifedata.com/resource/pubmed/id/14530735

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2003-10-7
pubmed:abstractText
Magnetic source imaging is claimed to have a high accuracy in epileptic focus localization and may be a guide for epilepsy surgery. Non-lesional mesiotemporal lobe epilepsy (MTLE), the most common form of epilepsy operated on, has different etiologies, which may affect the choice of surgical approach. The authors compared whole-head magnetoencephalography (MEG) with high-resolution EEG for source identification in MTLE. Nineteen patients with unilateral, nonlesional MTLE underwent a simultaneous 151-channel CTF MEG (CTF Systems, Inc., Port Coquitlam, British Columbia, Canada) and 64-channel EEG recordings with sleep induction. Three independent observers selected spikes from the EEG and MEG recordings separately. Only when there was interobserver agreement (kappa>0.4) on the presence of spikes in recordings were consensus spikes averaged. EEG and MEG equivalent current dipoles (ECD) were then integrated in the head model of the patient reconstructed from MRI. The results were compared with intraoperative electrocorticography findings. Spikes were detected in 32% of MEGs and 42% of EEGs. No patient showed MEG spikes only. Equivalent current dipole modeling correctly localized the source to the temporal lobe in four out of five MEG and three out of eight EEG recordings. MEG localized sources were more superficial and EEG localized sources were deeper. Unfortunately, basal temporal lobe areas were only partially covered by the sensor helmet of the MEG setup. Best correlation between EEG or MEG findings and electrocorticography findings was between horizontal EEG dipole orientation and prominent neocortical spiking; these patients also had a less favorable prognosis. Magnetic source imaging is currently unlikely to alter the surgical management of MTLE. The yield of spikes is too low, and ECD modeling shows only partial correlation with electrocorticography findings. Moreover, the whole-head MEG helmet provides insufficient coverage of the temporal lobe.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0736-0258
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
227-38
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
High-resolution source imaging in mesiotemporal lobe epilepsy: a comparison between MEG and simultaneous EEG.
pubmed:affiliation
Department of Clinical Neurophysiology, Rudolf Magnus Institute of Neuroscience, University of Utrect, The Netherlands. fleijten@neuro.azu.nl
pubmed:publicationType
Journal Article, Comparative Study