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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2003-10-6
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pubmed:abstractText |
Members of the Artemisia genus are important medicinal plants found throughout the world. Arteminolides A-D (1-4), isolated from the aerial parts of Artemisia, have an inhibitory activity on farnesyl-protein transferase (FPTase; EC 2.5.1.29) in in vitro assay. This study was carried out with the purpose of validating anti-tumor effects of the compounds in human tumor cells and mouse xenograft model. The arteminolides inhibited tumor cell growth in a dose-dependent manner. Furthermore, arteminolide C (3) blocked in vivo growth of human colon and lung tumor xenograft without the loss of body weight in nude mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0968-0896
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4545-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14527550-Alkyl and Aryl Transferases,
pubmed-meshheading:14527550-Animals,
pubmed-meshheading:14527550-Antineoplastic Agents,
pubmed-meshheading:14527550-Artemisia,
pubmed-meshheading:14527550-Cell Line, Tumor,
pubmed-meshheading:14527550-Enzyme Inhibitors,
pubmed-meshheading:14527550-Farnesyltranstransferase,
pubmed-meshheading:14527550-Humans,
pubmed-meshheading:14527550-Lactones,
pubmed-meshheading:14527550-Mice,
pubmed-meshheading:14527550-Mice, Nude,
pubmed-meshheading:14527550-Neoplasm Transplantation,
pubmed-meshheading:14527550-Phytotherapy,
pubmed-meshheading:14527550-Sesquiterpenes,
pubmed-meshheading:14527550-Tumor Suppressor Proteins,
pubmed-meshheading:14527550-Xenograft Model Antitumor Assays
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pubmed:year |
2003
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pubmed:articleTitle |
Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa.
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pubmed:affiliation |
Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosunggu, Taejeon 305-600, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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