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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2003-10-2
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pubmed:abstractText |
Most murine lung tumors are composed of differentiated epithelial cells. We have reported previously that surfactant protein (SP)-D is expressed in urethane-induced tumors. Serum levels of SP-D are increased in patients with interstitial lung disease and acute respiratory distress syndrome and in rats with acute lung injury but have not been measured in mice. In this study, we sought to determine whether SP-D could be detected in murine serum and discovered that it was increased in mice bearing lung tumors. Serum SP-D concentration was 5.0 +/- 0.2 ng/ml in normal C57BL/6 mice, essentially absent in SP-D nulls, and 63.6 +/- 9.0 ng/ml in SP-D-overexpressing mice. SP-D in serum was verified by immunoblotting. Serum SP-D was increased in mice bearing tumors induced by three different protocols, and the SP-D level correlated with tumor volume. However, in mice with a single adenoma or a few adenomas, SP-D levels were usually within the normal range. SP-D was expressed by the tumor cells, and there was also a field effect whereby type II cells near the tumor expressed more SP-D than type II cells in the remainder of the lung. Serum SP-D was also increased by lung inflammation. In airway inflammation induced by aerosolized ovalbumin in sensitized BALB/c mice, the serum levels were elevated after challenge. In conclusion, serum SP-D concentration is increased in mice bearing lung tumors and generally reflects the tumor burden but is also elevated during lung inflammation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0008-5472
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pubmed:author |
pubmed-author:Dwyer-NieldLori DLD,
pubmed-author:FisherJames HJH,
pubmed-author:GelfandErwin WEW,
pubmed-author:JakowlewSonia BSB,
pubmed-author:MalkinsonAlvin MAM,
pubmed-author:MasonRobert JRJ,
pubmed-author:MeyerAmy MAM,
pubmed-author:NielsenLarry DLD,
pubmed-author:TakedaKatsuyukiK,
pubmed-author:UmphressSarah MSM,
pubmed-author:WillettM AMA,
pubmed-author:ZhangFeijieF,
pubmed-author:ZhangLeningL
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5889-94
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14522914-Adenocarcinoma,
pubmed-meshheading:14522914-Animals,
pubmed-meshheading:14522914-Carcinogens,
pubmed-meshheading:14522914-Gene Deletion,
pubmed-meshheading:14522914-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:14522914-Genes, ras,
pubmed-meshheading:14522914-Lung Neoplasms,
pubmed-meshheading:14522914-Male,
pubmed-meshheading:14522914-Mice,
pubmed-meshheading:14522914-Mice, Inbred A,
pubmed-meshheading:14522914-Mice, Inbred BALB C,
pubmed-meshheading:14522914-Mice, Inbred C3H,
pubmed-meshheading:14522914-Mice, Transgenic,
pubmed-meshheading:14522914-Ovalbumin,
pubmed-meshheading:14522914-Pulmonary Surfactant-Associated Protein D,
pubmed-meshheading:14522914-Rats,
pubmed-meshheading:14522914-Transforming Growth Factor beta,
pubmed-meshheading:14522914-Urethane
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pubmed:year |
2003
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pubmed:articleTitle |
Serum levels of surfactant protein D are increased in mice with lung tumors.
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pubmed:affiliation |
National Jewish Medical and Research Center, Denver, Colorado 80206, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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