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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2003-10-2
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pubmed:abstractText |
We report the cloning and molecular characterization of a zebrafish pronociceptin gene, which is expressed in brain and intestine. This fish precursor codes for two different nociceptin peptides, one of which presents an opioid sequence in its N-terminus, being more similar to dynorphin A than its mammalian counterparts. Our results represent a new tool to investigate the function of nociceptin and its receptor in relation to pain and drug addiction.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-3002
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
1629
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
114-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:14522087-Amino Acid Sequence,
pubmed-meshheading:14522087-Animals,
pubmed-meshheading:14522087-Brain,
pubmed-meshheading:14522087-Cloning, Molecular,
pubmed-meshheading:14522087-Intestines,
pubmed-meshheading:14522087-Molecular Sequence Data,
pubmed-meshheading:14522087-Opioid Peptides,
pubmed-meshheading:14522087-Protein Precursors,
pubmed-meshheading:14522087-Receptors, Opioid,
pubmed-meshheading:14522087-Sequence Alignment,
pubmed-meshheading:14522087-Zebrafish
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pubmed:year |
2003
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pubmed:articleTitle |
Cloning and characterization of a full-length pronociceptin in zebrafish: evidence of the existence of two different nociceptin sequences in the same precursor.
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pubmed:affiliation |
Faculty of Medicine, Department of Biochemistry and Molecular Biology, University of Salamanca, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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