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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2004-5-10
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pubmed:abstractText |
Gene transfer into the amniotic fluid using recombinant adenovirus vectors was shown previously to result in high efficiency transfer of transgenes into the lungs and intestines. Adenovirus mediated in utero gene therapy, however, resulted in expression of the transgene for less than 30 days. Recombinant adenovirus associated viruses (rAAV) have the advantage of maintaining the viral genome in daughter cells thus providing for long-term expression of transgenes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14519209-10523208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14519209-10926557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14519209-11073714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14519209-11074369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14519209-11118354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14519209-11124065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14519209-11175309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14519209-11273769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14519209-11482982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14519209-1334463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14519209-2156265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14519209-7584996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14519209-9057739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14519209-9705235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14519209-9765395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14519209-9851885
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1472-6750
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
30
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
16
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:14519209-Amniotic Fluid,
pubmed-meshheading:14519209-Animals,
pubmed-meshheading:14519209-DNA,
pubmed-meshheading:14519209-DNA, Recombinant,
pubmed-meshheading:14519209-Dependovirus,
pubmed-meshheading:14519209-Fetus,
pubmed-meshheading:14519209-Gene Transfer Techniques,
pubmed-meshheading:14519209-Genes, Reporter,
pubmed-meshheading:14519209-Genetic Vectors,
pubmed-meshheading:14519209-Green Fluorescent Proteins,
pubmed-meshheading:14519209-Injections,
pubmed-meshheading:14519209-Intestines,
pubmed-meshheading:14519209-Luminescent Proteins,
pubmed-meshheading:14519209-Lung,
pubmed-meshheading:14519209-Macaca mulatta,
pubmed-meshheading:14519209-Mice,
pubmed-meshheading:14519209-Mice, Inbred C57BL,
pubmed-meshheading:14519209-Rats,
pubmed-meshheading:14519209-Rats, Sprague-Dawley,
pubmed-meshheading:14519209-Time Factors,
pubmed-meshheading:14519209-Transgenes
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pubmed:year |
2003
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pubmed:articleTitle |
In utero recombinant adeno-associated virus gene transfer in mice, rats, and primates.
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pubmed:affiliation |
Ochsner Children's Research Institute, Ochsner Clinic Foundation, New Orleans, LA 70121, USA. djgarre@aol.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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