Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2-3
|
pubmed:dateCreated |
1993-1-7
|
pubmed:abstractText |
The influence of pertussis toxin (PTX) on thermic responses elicited by morphine and neurotensin was evaluated in unrestrained rats kept at 22 degrees C. High doses of morphine (9-36 micrograms/rat i.c.v.) lowered body temperature and low doses (1.25, 2.5 micrograms/rat i.c.v.) produced hyperthermia. The hyperthermic effect was more resistant than the hypothermic effect to naloxone antagonism. Neurotensin (50, 100 micrograms/rat i.c.v.) induced marked hypothermia followed by hyperthermia. I.c.v. injection of PTX (1 microgram), six days before morphine (18 micrograms/rat i.c.v.), replaced the opiate hypothermia by consistent hyperthermia and reduced by 60% the hyperthermia elicited by morphine (2.5 micrograms/rat i.c.v.). The toxin also affected the thermic responses induced by neurotensin (50 micrograms/rat i.c.v.) administered six days after PTX (1 microgram/rat i.c.v.). The initial hypothermia was enhanced by 173% and the late hyperthermia was fully antagonized. It thus appears that PTX-sensitive G-proteins play different roles in the molecular events underlying the thermoregulatory responses to morphine and neurotensin.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0014-2999
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
10
|
pubmed:volume |
222
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
241-5
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:1451736-Animals,
pubmed-meshheading:1451736-Body Temperature,
pubmed-meshheading:1451736-Drug Interactions,
pubmed-meshheading:1451736-Female,
pubmed-meshheading:1451736-Injections, Intraventricular,
pubmed-meshheading:1451736-Morphine,
pubmed-meshheading:1451736-Neurotensin,
pubmed-meshheading:1451736-Pertussis Toxin,
pubmed-meshheading:1451736-Rats,
pubmed-meshheading:1451736-Rats, Sprague-Dawley,
pubmed-meshheading:1451736-Virulence Factors, Bordetella
|
pubmed:year |
1992
|
pubmed:articleTitle |
Influence of pertussis toxin on thermic responses to morphine and neurotensin in rats.
|
pubmed:affiliation |
Institute of Pharmacology, Faculty of Sciences, University of Milan, Italy.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|