Source:http://linkedlifedata.com/resource/pubmed/id/14515257
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rdf:type | |
lifeskim:mentions |
umls-concept:C0003451,
umls-concept:C0005516,
umls-concept:C0017262,
umls-concept:C0039194,
umls-concept:C0042769,
umls-concept:C0085358,
umls-concept:C0185117,
umls-concept:C0205178,
umls-concept:C0439677,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2698600,
umls-concept:C2911684
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pubmed:issue |
10
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pubmed:dateCreated |
2003-9-29
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pubmed:abstractText |
CD11b, CD11c, and F4/80 are normally used to define dendritic cell and/or macrophage populations. In this study, the expression of all three markers was observed on CD8(+) T cells following infection of mice with several distinct viruses. Using lymphocytic choriomeningitis virus as a model virus, it was found that relatively more CD11b(+)CD8(+) and CD11c(+)CD8(+) T cells were present in the periphery than in primary lymphoid organs; in contrast, the F4/80(+)CD8(+) T cell population was more prevalent in the spleen. All three myeloid markers were detected on virus-specific CTL. The expression of CD11b and CD11c on CD8(+) T cells correlated with their level of CTL activity, whereas the F4/80(+)CD8(+) T cell population increased after the peak of the CTL response but did not have higher CTL activity. These data suggest that there is a differential induction of CD11b, CD11c, and F4/80 on virus-specific CD8(+) T cells following an acute virus infection.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-2980
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2736-43
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:14515257-Acute Disease,
pubmed-meshheading:14515257-Animals,
pubmed-meshheading:14515257-Antigens, CD11b,
pubmed-meshheading:14515257-Antigens, CD11c,
pubmed-meshheading:14515257-Antigens, Differentiation,
pubmed-meshheading:14515257-CD8-Positive T-Lymphocytes,
pubmed-meshheading:14515257-Female,
pubmed-meshheading:14515257-Lymphocytic Choriomeningitis,
pubmed-meshheading:14515257-Male,
pubmed-meshheading:14515257-Mice,
pubmed-meshheading:14515257-Mice, Inbred BALB C,
pubmed-meshheading:14515257-Mice, Inbred C57BL,
pubmed-meshheading:14515257-T-Lymphocytes, Cytotoxic
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pubmed:year |
2003
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pubmed:articleTitle |
Myeloid marker expression on antiviral CD8+ T cells following an acute virus infection.
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pubmed:affiliation |
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis 46202, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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