Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2003-10-21
pubmed:abstractText
The risk factors for development of paradoxical response were studied in a cohort of 104 patients with culture-documented Mycobacterium tuberculosis infection. Paradoxical deterioration occurred in 16 (15.4%) patients (case group) during antituberculosis therapy, involving lungs and pleura (n=4), spine and paraspinal tissue (n=5), intracranium (n=3), peritoneum (n=2), bone and joint (n=1), and lymph node (n=1). The median time from commencement of treatment to paradoxical deterioration was 56 days (range, 20-109 days). Compared with 53 patients without clinical deterioration after antituberculosis therapy (control group), patients with paradoxical response were more likely to have extrapulmonary involvement (62.5% vs. 17.0%; P<0.05) at initial diagnosis, to have lower baseline lymphocyte counts (672+/-315 cells/microl vs. 1,328+/-467 cells/microl; P<0.001), and to exhibit a greater surge in lymphocyte counts (627+/-465 cells/microl vs. 225+/-216 cells/microl; P<0.05) during paradoxical response. Further studies on lymphocyte subsets and cytokine levels would be useful in understanding the exact immunological mechanisms involved in immunorestitution.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0934-9723
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
597-602
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:14508660-Adult, pubmed-meshheading:14508660-Age Distribution, pubmed-meshheading:14508660-Aged, pubmed-meshheading:14508660-Antitubercular Agents, pubmed-meshheading:14508660-Case-Control Studies, pubmed-meshheading:14508660-Chi-Square Distribution, pubmed-meshheading:14508660-Cohort Studies, pubmed-meshheading:14508660-Disease Progression, pubmed-meshheading:14508660-Female, pubmed-meshheading:14508660-Follow-Up Studies, pubmed-meshheading:14508660-HIV Seronegativity, pubmed-meshheading:14508660-Humans, pubmed-meshheading:14508660-Incidence, pubmed-meshheading:14508660-Male, pubmed-meshheading:14508660-Middle Aged, pubmed-meshheading:14508660-Mycobacterium tuberculosis, pubmed-meshheading:14508660-Probability, pubmed-meshheading:14508660-Risk Assessment, pubmed-meshheading:14508660-Severity of Illness Index, pubmed-meshheading:14508660-Sex Distribution, pubmed-meshheading:14508660-Treatment Outcome, pubmed-meshheading:14508660-Tuberculin Test, pubmed-meshheading:14508660-Tuberculosis, Pulmonary
pubmed:year
2003
pubmed:articleTitle
Risk factors for development of paradoxical response during antituberculosis therapy in HIV-negative patients.
pubmed:affiliation
Division of Infectious Diseases, Center of Infection, University Pathology Building, The University of Hong Kong, Queen Mary Hospital, Hong Kong.
pubmed:publicationType
Journal Article, Comparative Study