14507179

Source:http://linkedlifedata.com/resource/pubmed/id/14507179

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0443286, umls-concept:C0597328
pubmed:issue	20
pubmed:dateCreated	2003-9-25
pubmed:abstractText	[reaction: see text] A microwave-assisted reaction was developed to facilitate the construction of 4,5-disubstituted pyrazolopyrimidines. This one-pot two-step process involves a sequential S(N)Ar displacement of the C4 chloro substituent with various anilines and amines, followed by a Suzuki coupling reaction with different boronic acids. Using microwave irradiation leads to high product conversion, low side product formation, and shorter reactions.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/100890393
pubmed:status	PubMed-not-MEDLINE
pubmed:month	Oct
pubmed:issn	1523-7060
pubmed:author	pubmed-author:DingShengS, pubmed-author:SchultzPeter GPG, pubmed-author:WuTom Y HTY
pubmed:issnType	Print
pubmed:day	2
pubmed:volume	5
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3587-90
pubmed:year	2003
pubmed:articleTitle	One-pot two-step microwave-assisted reaction in constructing 4,5-disubstituted pyrazolopyrimidines.
pubmed:affiliation	Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
pubmed:publicationType	Journal Article