Source:http://linkedlifedata.com/resource/pubmed/id/14503643
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2003-9-23
|
| pubmed:abstractText |
Recent work on frontotemporal dementia (FTD) has revealed the existence of at least 3 genetically distinct groups of inherited FTD: FTDP-17, FTD and motor neuron disease linked to chromosome 9, and FTD linked to chromosome 3 (FTD-3). Tau, on chromosome 17, is the only gene where mutations have been identified and its involvement in FTD has been firmly established. The genes on chromosome 9 and chromosome 3 associated with familial forms of FTD remain to be identified. Abnormal aggregates of tau protein characterize the brain lesions of FTDP-17 patients and ubiquitin inclusions have been found in FTD with motor neuron disease linked to chromosome 9. In this study the frontal cortices of 3 FTD-3 patients from a unique Danish family were examined for characteristic neuropathological features. In these brains tau inclusions were present in neurons and some glial cells in the absence of beta-amyloid deposits. The presence of filamentous tau protein in the frontal cortex of these patients suggests a possible link between tau and the genetic defect present on chromosome 3 and associated with FTD-3, although the limited amount of tau deposits observed makes it difficult to define this as a tauopathy.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Neurofilament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ribosomal protein S30,
http://linkedlifedata.com/resource/pubmed/chemical/tau Proteins
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
|
| pubmed:issn |
0022-3069
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
62
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
878-82
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| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:14503643-Aged,
pubmed-meshheading:14503643-Amyloid beta-Peptides,
pubmed-meshheading:14503643-Chromosomes, Human, Pair 3,
pubmed-meshheading:14503643-Dementia,
pubmed-meshheading:14503643-Family Health,
pubmed-meshheading:14503643-Frontal Lobe,
pubmed-meshheading:14503643-Genetic Linkage,
pubmed-meshheading:14503643-Humans,
pubmed-meshheading:14503643-Immunoblotting,
pubmed-meshheading:14503643-Immunohistochemistry,
pubmed-meshheading:14503643-Microscopy, Immunoelectron,
pubmed-meshheading:14503643-Middle Aged,
pubmed-meshheading:14503643-Neurofilament Proteins,
pubmed-meshheading:14503643-Neurons,
pubmed-meshheading:14503643-Oligodendroglia,
pubmed-meshheading:14503643-Protein Isoforms,
pubmed-meshheading:14503643-Ribosomal Proteins,
pubmed-meshheading:14503643-tau Proteins
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Tau protein in frontotemporal dementia linked to chromosome 3 (FTD-3).
|
| pubmed:affiliation |
Brain Repair Centre and Department of Neurology, University of Cambridge, Cambridge, UK.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|