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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2003-9-22
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pubmed:abstractText |
A global conformational space of 6253 dinucleoside monophosphate (DMP) units consisting of RNA and DNA (free and protein/drug-bound) was 'mapped' using high resolution crystal structures cataloged in the Nucleic Acid Database (NDB). The torsion angles of each DMP were clustered in a reduced three-dimensional space using a classical multi-dimensional scaling method. The mapping of the conformational space reveals nine primary clusters which distinguish among the common A-, B- and Z-forms and their various substates, plus five secondary clusters for kinked or bent structures. Conformational relationships and possible transitional pathways among the substates are also examined using the conformational states of DNA and RNA bound with proteins or drugs as potential pathway intermediates.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-10222198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-10388766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-10438623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-10499579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-10699843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-11222771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-11390969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-11416174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-11509180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-11580248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-11604040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-11676540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-12235390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-1384741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-13990617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-1995328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-2369616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-2482757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-2722771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-3310237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-5079964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-514347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-6726797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-7538626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14500824-9878364
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1362-4962
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5607-16
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:14500824-Algorithms,
pubmed-meshheading:14500824-DNA,
pubmed-meshheading:14500824-DNA-Binding Proteins,
pubmed-meshheading:14500824-Dinucleoside Phosphates,
pubmed-meshheading:14500824-Models, Molecular,
pubmed-meshheading:14500824-Molecular Structure,
pubmed-meshheading:14500824-Nucleic Acid Conformation,
pubmed-meshheading:14500824-Principal Component Analysis,
pubmed-meshheading:14500824-RNA,
pubmed-meshheading:14500824-RNA-Binding Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
Global mapping of nucleic acid conformational space: dinucleoside monophosphate conformations and transition pathways among conformational classes.
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pubmed:affiliation |
Department of Chemistry, University of California at Berkeley and Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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