Source:http://linkedlifedata.com/resource/pubmed/id/14499451
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
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| pubmed:dateCreated |
2003-9-22
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| pubmed:abstractText |
Neuropathic pain and epileptic seizures bear several similarities, among them is the response to anticonvulsant drugs. It has therefore been hypothesized that epileptiform activity of nociceptive spinal dorsal horn neurons may contribute to paroxysmal forms of neuropathic pain. We used patch-clamp and field potential recordings from young rat spinal cord slices to test if nociceptive dorsal horn structures are indeed able to sustain epileptiform activity. Application of the convulsant 4-aminopyridine (100 microM) evoked epileptiform activity that was most pronounced in superficial dorsal horn and involved nociceptive lamina I neurons with a projection to the brain. The epileptiform activity was dependent on fast excitatory and inhibitory synaptic transmission through ionotropic glutamate receptors and GABA(A) receptors. During epileptiform activity, previously silent polysynaptic pathways from primary afferent C-fibers to superficial dorsal horn neurons were opened. Stimulation of primary afferents at Adelta- and C-fiber intensity interfered with the epileptiform rhythm, suggesting that both affect the same dorsal horn structures. Similar to neuropathic pain, spinal dorsal horn epileptiform activity was much less reduced by classical analgesics than by anticonvulsant agents.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0304-3959
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
105
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
327-38
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:14499451-4-Aminopyridine,
pubmed-meshheading:14499451-Afferent Pathways,
pubmed-meshheading:14499451-Analgesics,
pubmed-meshheading:14499451-Animals,
pubmed-meshheading:14499451-Brain,
pubmed-meshheading:14499451-Convulsants,
pubmed-meshheading:14499451-Electrophysiology,
pubmed-meshheading:14499451-Epilepsy,
pubmed-meshheading:14499451-Excitatory Postsynaptic Potentials,
pubmed-meshheading:14499451-Nerve Net,
pubmed-meshheading:14499451-Neural Inhibition,
pubmed-meshheading:14499451-Neuralgia,
pubmed-meshheading:14499451-Nociceptors,
pubmed-meshheading:14499451-Posterior Horn Cells,
pubmed-meshheading:14499451-Rats,
pubmed-meshheading:14499451-Rats, Sprague-Dawley,
pubmed-meshheading:14499451-Spinal Cord,
pubmed-meshheading:14499451-Synapses,
pubmed-meshheading:14499451-Synaptic Transmission
|
| pubmed:year |
2003
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| pubmed:articleTitle |
Epileptiform activity in rat spinal dorsal horn in vitro has common features with neuropathic pain.
|
| pubmed:affiliation |
Brain Research Institute, Vienna University, Vienna, Austria.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|