Source:http://linkedlifedata.com/resource/pubmed/id/14354107
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1955-12-1
|
| pubmed:abstractText |
A method has been described for the preparation of Treponema pallidum suspensions that are suitable for specific agglutination studies and can be stored at 4 degrees C. for months without loss of agglutinability. Such suspensions have been shown to react with two distinct antibodies in the serum of syphilitic animals and man: Wassermann antibody and a specific treponeme agglutinin. It has been demonstrated that the agglutination of treponemes by specific treponeme agglutinin is enhanced by heat treatment or aging of the suspension, and inhibited by a divalent cation, probably Ca(++), normally present in serum. This inhibition has been overcome by the use of a chelating agent, ethylene-diamine tetracetate. These findings have been utilized to devise a simple agglutination test for the diagnosis of treponeme infections that is very sensitive and highly specific. This test has been carried out with 430 human sera, and a comparison has been made of the results of the agglutination, treponemal immobilization, and standard serological tests on these sera. The agglutination test appears to have a specificity comparable to the treponemal immobilization test and considerably greater than the standard serological tests.
|
| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/14354107-13074457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14354107-13159189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14354107-13197697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14354107-14829442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14354107-14888379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14354107-14955455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14354107-18113911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14354107-19867681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14354107-19867892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14354107-19867992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14354107-19868045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14354107-19868060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/14354107-19870883
|
| pubmed:keyword | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
OM
|
| pubmed:status |
OLDMEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0022-1007
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
101
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
367-82
|
| pubmed:dateRevised |
2010-9-21
|
| pubmed:meshHeading | |
| pubmed:year |
1955
|
| pubmed:articleTitle |
Specific agglutination of Treponema pallidum by sera from rabbits and human beings with treponemal infections.
|
| pubmed:publicationType |
Journal Article
|