|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1992-12-22
|
|
pubmed:abstractText |
Inclusion of ketonazole (in a daily dose of 400 mg/kg for 8 days) into the diet of intact and cholesterol-fed (5% dietary cholesterol) rats produced a respective 20- and 30-percent lowering of cholesterol content in blood serum. In all the animals, the hypocholesterolemic effect of ketoconazole was realized via a decrease of the concentration of very low and low density lipoproteins. Ketoconazole also gave rise to a reduction of the concentration of cholesterol and bile acids in bile of the intact rats and of cholesterol in bile of the cholesterol-fed animals.
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|
pubmed:language |
rus
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0869-2092
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
55
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
47-9
|
|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:1422455-Animals,
pubmed-meshheading:1422455-Anticholesteremic Agents,
pubmed-meshheading:1422455-Bile,
pubmed-meshheading:1422455-Cholesterol,
pubmed-meshheading:1422455-Cholesterol, Dietary,
pubmed-meshheading:1422455-Drug Evaluation, Preclinical,
pubmed-meshheading:1422455-Hypercholesterolemia,
pubmed-meshheading:1422455-Ketoconazole,
pubmed-meshheading:1422455-Lipoproteins,
pubmed-meshheading:1422455-Male,
pubmed-meshheading:1422455-Rats
|
|
pubmed:articleTitle |
[The effect of ketoconazole on the cholesterol content of the blood serum lipoproteins and bile in experimental hypercholesterolemia].
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|
pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
|
