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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1992-12-1
|
| pubmed:databankReference | |
| pubmed:abstractText |
We have characterized a growth factor-inducible gene, pghs-B, isolated by differential screening of a lambda complementary DNA library from RNA of serum-stimulated NIH 3T3 cells which encodes a 604-amino acid protein presenting high similarity with prostaglandin G/H synthase (PGHS). Induction of both pghs-B mRNA and protein is rapid and remains at high levels for several hours. The increase in pghs-B mRNA is mainly due to transcriptional activation of the gene. PGHS-B has been expressed in the baculovirus system and has been demonstrated to be involved in prostaglandin synthesis and to be inhibited by indomethacin, demonstrating that PGHS-B is indeed an enzyme related to PGHS. The pghs-B gene maps to the [1G-1H2] region of the murine genome.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1044-9523
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:geneSymbol |
pghs-B
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
443-50
|
| pubmed:dateRevised |
2006-4-21
|
| pubmed:meshHeading |
pubmed-meshheading:1419907-3T3 Cells,
pubmed-meshheading:1419907-Amino Acid Sequence,
pubmed-meshheading:1419907-Animals,
pubmed-meshheading:1419907-Baculoviridae,
pubmed-meshheading:1419907-Base Sequence,
pubmed-meshheading:1419907-Chromosome Mapping,
pubmed-meshheading:1419907-Cyclooxygenase 2,
pubmed-meshheading:1419907-DNA,
pubmed-meshheading:1419907-Enzyme Induction,
pubmed-meshheading:1419907-Genes,
pubmed-meshheading:1419907-Genetic Vectors,
pubmed-meshheading:1419907-Male,
pubmed-meshheading:1419907-Mice,
pubmed-meshheading:1419907-Mice, Inbred BALB C,
pubmed-meshheading:1419907-Mice, Mutant Strains,
pubmed-meshheading:1419907-Molecular Sequence Data,
pubmed-meshheading:1419907-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:1419907-Recombinant Fusion Proteins,
pubmed-meshheading:1419907-Transcription, Genetic
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity.
|
| pubmed:affiliation |
Department of Molecular Biology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000.
|
| pubmed:publicationType |
Journal Article
|