Linked Life Data

1411382

Source:http://linkedlifedata.com/resource/pubmed/id/1411382

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1992-10-29
pubmed:abstractText
Fewer than 50 chemicals, groups of chemicals, or mixtures have been causally linked with cancer in humans. Some 250 chemicals have, however, been found to be carcinogenic to rodents. Carcinogenic risk factors that have been identified for humans occur in clearly quantifiable exposure situations, but epidemiologic information on cancer in humans is missing or inadequate for the great majority of chemicals. Extrapolation of animal data to humans is complicated because long-term carcinogenicity studies on animals are carried out under simplified conditions, whereas humans are exposed to a multitude of exogenous and endogenous agents. Furthermore, the carcinogenic process includes multistage and multifactorial aspects, and human populations are genetically and physiologically heterogeneous. Although the science of carcinogenesis is making rapid progress in terms of understanding some of these processes and interactions, there is still a need to err on the side of safety and accept animal data as a warning signal for possible human effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0355-3140
pubmed:author
pubmed:issnType
Print
pubmed:volume
18 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
64-73
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Identification of carcinogens within the IARC monograph program.
pubmed:affiliation
International Agency for Research on Cancer, Lyon, France.
pubmed:publicationType
Journal Article, Review