|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
19
|
|
pubmed:dateCreated |
1992-11-10
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
We isolated cDNA clones containing the entire coding region of the putative oncogene AKT2. Sequence analysis and in vitro translation demonstrated that AKT2 encodes a 56-kDa protein with homology to serine/threonine kinases; moreover, this protein contains a Src homology 2-like domain. AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. AKT2 was mapped to chromosome region 19q13.1-q13.2 by fluorescence in situ hybridization. In the two ovarian carcinoma cell lines exhibiting amplification of AKT2, the amplified sequences were localized within homogeneously staining regions. We conclude that AKT2 belongs to a distinct subfamily of protein-serine/threonine kinases containing Src homology 2-like domains and that alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-1377010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-1708916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-1801921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-1833819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-1851997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-197531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-2073841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-2176544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-2180580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-2201023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-2336401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-2342480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-2558854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-2577136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-2647292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-2832508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-2834397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-2837282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-3037531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-3078956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-3285294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-3291115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-3541204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-3670047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-3798106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-3941898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-4028028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-6173755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-6546423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-6604576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1409633-6719137
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
89
|
|
pubmed:geneSymbol |
AKT1,
AKT2,
v-akt
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
9267-71
|
|
pubmed:dateRevised |
2010-9-7
|
|
pubmed:meshHeading |
pubmed-meshheading:1409633-Humans,
pubmed-meshheading:1409633-Ovarian Neoplasms,
pubmed-meshheading:1409633-Lymphocytes,
pubmed-meshheading:1409633-Fluorescent Dyes,
pubmed-meshheading:1409633-Female,
pubmed-meshheading:1409633-DNA,
pubmed-meshheading:1409633-Protein Biosynthesis,
pubmed-meshheading:1409633-Amino Acid Sequence,
pubmed-meshheading:1409633-Chromosomes, Human,
pubmed-meshheading:1409633-Molecular Sequence Data,
pubmed-meshheading:1409633-Transcription, Genetic,
pubmed-meshheading:1409633-Cloning, Molecular,
pubmed-meshheading:1409633-Sequence Homology, Amino Acid,
pubmed-meshheading:1409633-Multigene Family,
pubmed-meshheading:1409633-Gene Amplification,
pubmed-meshheading:1409633-Oncogenes,
pubmed-meshheading:1409633-Protein-Serine-Threonine Kinases,
pubmed-meshheading:1409633-Gene Library
|
