Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1992-11-16
pubmed:abstractText
We have determined the different Fos/Jun complexes present in Swiss 3T3 cells either following serum stimulation of quiescent cells or during exponential growth by immunoprecipitation analyses. We have shown that while c-Fos is the major Fos protein associated with the Jun proteins (c-Jun, JunB, and JunD) soon after serum stimulation, at later times Fra-1 and Fra-2 are the predominant Fos proteins associated with the different Jun proteins. During exponential growth, the synthesis of Fra-1 and Fra-2 is maintained at a significant level, in contrast to c-Fos and FosB, which are expressed at very low or undetectable levels. Consequently, Fra-1 and Fra-2 are the main Fos proteins complexed with the Jun proteins in asynchronously growing cells. To determine whether the Fos proteins are differentially required during the G0-to-G1 transition and exponential growth for the entrance into S phase, we microinjected affinity-purified antibodies directed against c-Fos, FosB, Fra-1, and Fra-2. We have found that while the activities of c-Fos and FosB are required mostly during the G0-to-G1 transition, Fra-1 and Fra-2 are involved both in the G0-to-G1 transition and in asynchronous growth.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-1562737, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-1751545, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-1827665, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-1883198, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-1900040, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-1901942, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-1903195, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-1905017, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-1908553, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-1922060, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-1931831, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-1945831, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-2107490, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-2110368, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-2454395, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-2457172, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-2458952, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-2467839, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-2493644, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-2497053, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-2498083, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-2513128, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-2513129, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-2648396, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-3034432, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-3034433, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-3133553, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-3136397, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-3142691, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-3142692, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-3149716, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-3186736, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-3422745, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-3523478, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-3547078, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-6090941, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-6334806, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-6514007, http://linkedlifedata.com/resource/pubmed/commentcorrection/1406676-6607118
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0270-7306
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5015-23
pubmed:dateRevised
2010-9-7
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Existence of different Fos/Jun complexes during the G0-to-G1 transition and during exponential growth in mouse fibroblasts: differential role of Fos proteins.
pubmed:affiliation
Department of Molecular Biology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000.
pubmed:publicationType
Journal Article