Linked Life Data

14045347

Source:http://linkedlifedata.com/resource/pubmed/id/14045347

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1964-1-1
pubmed:abstractText
Twenty-eight electrocardiograms are presented which depict a quinidine-like effect of thioridazine on ventricular repolarization, in doses as low as 200 mg. a day. T waves have been found to flatten out and sometimes invert. Occasionally S-T segments have become convex and U waves have appeared.Case reports are presented of two patients who died while receiving large doses of thioridazine, 1500 and 3600 mg. daily, respectively. Terminal ECG patterns in each instance were those of heart block, alternating with episodes of ventricular tachycardia.The myocardium of one of the fatal cases revealed edema, increased vascularity, and some increase in connective tissue elements, along with fragmentation of muscle fibers. These changes were most pronounced in the interventricular septum.It is concluded that, because of the quinidine-like action of thioridazine on ventricular repolarization, caution is indicated when it is administered in large doses.
pubmed:commentsCorrections
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
OM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0008-4409
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
546-54
pubmed:dateRevised
2011-9-28
pubmed:meshHeading
pubmed:year
1963
pubmed:articleTitle
THIORIDAZINE HYDROCHLORIDE (MELLARIL): ITS EFFECT ON THE ELECTROCARDIOGRAM AND A REPORT OF TWO FATALITIES WITH ELECTROCARDIOGRAPHIC ABNORMALITIES.
pubmed:publicationType
Journal Article