Linked Life Data

1403681

Source:http://linkedlifedata.com/resource/pubmed/id/1403681

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1992-10-26
pubmed:abstractText
Reaction of some picolines 5 with 1-chloro-2,4-dinitrobenzene (6) in acetone furnished methyl-substituted 2,4-dinitrophenylpyridinium chlorides 7. Further reaction with phenyl(pyridyl)carbonyl hydrazides 8 at room temperature furnished isolable 2,4-dinitroanilino derivatives 9, which were then refluxed in a water:dioxane mixture (1:4, v/v) to furnish the methyl-substituted phenyl(pyridyl)carbonyl iminopyridinium ylides 10. Reduction of the ylides with NaBH4 finally gave rise to the desired methyl-substituted phenyl(pyridyl)carbonylamino-1,2,3,6-tetrahydropyridines 11. The anti-inflammatory activities of 11a-11l were determined with the carrageenan-soaked sponge model of inflammation in Sprague-Dawley rats, and the analgesic effects of these derivatives were assessed by suppression of acetic acid-induced writhing in male Swiss albino mice. All compounds tested showed moderate to good anti-inflammatory and analgesic effects compared with indomethacin. Compound 11k was the most active analgesic, and 11h was the most effective anti-inflammatory agent among the methyl-substituted tetrahydropyridines.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-3549
pubmed:author
pubmed:issnType
Print
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
463-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Synthesis and pharmacological evaluation of some N-[pyridyl(phenyl)carbonylamino]methyl-1,2,3,6-tetrahydropyrid ines.
pubmed:affiliation
College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee 32307.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.