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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1992-11-10
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pubmed:abstractText |
The HIV Tat protein is able to upregulate the transcription by RNA polymerase III of cotransfected or endogenous cellular Alu-repeated sequences in both HeLa and Jurkat T cells. This effect is mediated by an increase in the activity of transcription factor TFIIIC, which binds to the B box in the RNA polymerase III Alu promoter. This is the first example of an effect of the Tat protein on the transcription of a cellular gene or on the activity of a cellular transcription factor. The significance of this effect for the life cycle of HIV and its interaction with infected cells is discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, tat,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, TFIII,
http://linkedlifedata.com/resource/pubmed/chemical/tat Gene Products, Human...,
http://linkedlifedata.com/resource/pubmed/chemical/transcription factor TFIIIC
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pubmed:status |
MEDLINE
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pubmed:issn |
0894-9255
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:geneSymbol |
tat
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1142-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1403646-Actins,
pubmed-meshheading:1403646-Base Sequence,
pubmed-meshheading:1403646-Cell Line,
pubmed-meshheading:1403646-DNA, Viral,
pubmed-meshheading:1403646-Gene Expression Regulation, Viral,
pubmed-meshheading:1403646-Gene Products, tat,
pubmed-meshheading:1403646-HIV,
pubmed-meshheading:1403646-HeLa Cells,
pubmed-meshheading:1403646-Humans,
pubmed-meshheading:1403646-Molecular Sequence Data,
pubmed-meshheading:1403646-Oligonucleotides,
pubmed-meshheading:1403646-Promoter Regions, Genetic,
pubmed-meshheading:1403646-RNA, Messenger,
pubmed-meshheading:1403646-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:1403646-Transcription, Genetic,
pubmed-meshheading:1403646-Transcription Factors,
pubmed-meshheading:1403646-Transcription Factors, TFIII,
pubmed-meshheading:1403646-Transfection,
pubmed-meshheading:1403646-tat Gene Products, Human Immunodeficiency Virus
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pubmed:year |
1992
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pubmed:articleTitle |
The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC.
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pubmed:affiliation |
Department of Biochemistry, University College and Middlesex School of Medicine, London, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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