Linked Life Data

1397843

Source:http://linkedlifedata.com/resource/pubmed/id/1397843

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1992-11-19
pubmed:abstractText
B lymphocytes express multisubunit receptors for antigen that play multiple roles in generation of the immune response. These receptors act as transmembrane signal transducers but also act to capture, concentrate, and internalize antigen for subsequent proteolytic processing and presentation to T cells. During the past decade great progress has been made in our understanding of the extended structure of the receptor and the molecular basis by which it transduces signals. It is now clear that the B cell antigen receptor is a complex structure composed of antigen binding and transducer/transporter substructures. The antigen binding substructure is composed of disulfide-linked immunoglobulin H and L chains, and is noncovalently associated with transducer/transporter substructures composed of disulfide-linked heterodimers of alpha, beta, and gamma chain products of the mb-1 (alpha) and B29 (beta and gamma) genes. The cytoplasmic tails of these chains associate with src-family tyrosine kinases including fyn, lyn, blk, and lck and other SH2-containing molecules such as phosphatidylinositol 3-kinase. Available evidence indicates that these interactions are mediated via an amino acid sequence motif of approximately 22 amino acids that is found in both alpha and beta chains. Receptor ligation triggers the activation of multiple receptor-associated src-family kinases leading to phosphorylation and activation of PLC gamma 1 and PLC gamma 2. Subsequent phosphoinositide hydrolysis and calcium mobilization, presumably acting in concert with other tyrosine kinase-activated mechanisms, leads to transcriptional activation of a number of immediate early genes and, ultimately, to B cell proliferation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0892-6638
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:geneSymbol
mb-1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3207-17
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Membrane immunoglobulin and its accomplices: new lessons from an old receptor.
pubmed:affiliation
Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado.
pubmed:publicationType
Journal Article, Review