Linked Life Data

1397704

Source:http://linkedlifedata.com/resource/pubmed/id/1397704

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1992-10-26
pubmed:abstractText
The VLDL and LDL fractions were isolated from 29 patients with type 1 diabetes at the time of admission to the hospital to restore glycemic control and again at discharge. These lipoprotein fractions were incubated with human monocyte-derived macrophages, and the rates of macrophage CE synthesis were determined. The rates of CE synthesis in human macrophages were significantly greater (P less than 0.005) when incubated with VLDL isolated from type I diabetic patients before compared with after glycemic control was attained and averaged 1.84 +/- 0.52 and 1.09 +/- 0.27 nmol (1.20 +/- 0.34 and 0.71 +/- 0.18 micrograms) [14C]cholesteryl oleate synthesized.mg cell protein-1 x 20 h-1, respectively. In contrast, when LDL isolated from the same patient during the same period was incubated with human macrophages, the rates of cellular cholesteryl ester synthesis did not differ significantly and averaged 4.23 +/- 1.26 and 3.91 +/- 0.96 nmol (2.75 +/- 0.82 and 2.55 +/- 0.63 micrograms) [14C]cholesteryl oleate synthesized.mg-1 cell protein.20 h-1, respectively. There was a significant increase in the total cholesterol content of VLDL isolated before glycemic control compared with that isolated after glycemic control was attained (P less than 0.05) resulting from a significant increase in the FC and CE (P less than 0.05) contents of these VLDL particles. There was a significant decrease in the ratio of FC to PL in VLDL, but not LDL, isolated after glycemic control (P less than 0.05). The percentage of apoE in VLDL was significantly decreased (P less than 0.05) after glycemic control was attained.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0012-1797
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1301-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Influence of glycemic control on interaction of very-low- and low-density lipoproteins isolated from type I diabetic patients with human monocyte-derived macrophages.
pubmed:affiliation
Research Service, Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, South Carolina 29401-5799.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, Non-P.H.S.