|
pubmed:abstractText |
ALTHOUGH THE LIVERS OF RATS TREATED WITH AGENTS KNOWN TO SUPPRESS BILIRUBIN TRANSPORT APPEARED RELATIVELY NORMAL ON ROUTINE HISTOLOGICAL SECTIONS, CYTOCHEMICAL AND ELECTRON MICROSCOPIC PREPARATIONS REVEALED MARKED CHANGES IN: (a) levels of alkaline phosphatase and apparent ATPase activities of the cell membrane at the sinusoids, bile canaliculi, and between adjacent cells; (b) morphology of the bile canaliculi such as dilatation, fragmentation, vesiculation and reduced numbers of microvilli; (c) the number of lysosomes and their distribution within the cell. Similar changes in the cytochemistry of the liver cell were induced by extrahepatic obstruction.
|
