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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5069
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pubmed:dateCreated |
1992-8-26
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pubmed:databankReference |
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pubmed:abstractText |
A t(17;19) chromosomal translocation in early B-lineage acute leukemia was shown to result in chimeric transcripts that contain sequences from the E2A basic helix-loop-helix transcription factor gene on chromosome 19, fused to sequences from a previously unidentified gene (HLF) on chromosome 17 that encodes a hepatic leukemia factor. The chimeric protein consisted of the amino-terminal transactivation domain of E2A linked to the carboxyl-terminal basic region-leucine zipper domain of HLF. HLF was normally expressed in liver and kidney, but not in lymphoid cells, and was found to be closely related to the leucine zipper-containing transcription factors DBP (albumin D-box binding protein) and TEF (thyrotroph embryonic factor), which regulate developmental stage-specific gene expression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
257
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pubmed:geneSymbol |
E2A,
HLF
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
531-4
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1386162-Adenovirus Early Proteins,
pubmed-meshheading:1386162-Amino Acid Sequence,
pubmed-meshheading:1386162-Base Sequence,
pubmed-meshheading:1386162-Blotting, Northern,
pubmed-meshheading:1386162-Burkitt Lymphoma,
pubmed-meshheading:1386162-Cell Line,
pubmed-meshheading:1386162-Chromosomes, Human, Pair 17,
pubmed-meshheading:1386162-Chromosomes, Human, Pair 19,
pubmed-meshheading:1386162-Cloning, Molecular,
pubmed-meshheading:1386162-Humans,
pubmed-meshheading:1386162-Leucine Zippers,
pubmed-meshheading:1386162-Molecular Sequence Data,
pubmed-meshheading:1386162-Multigene Family,
pubmed-meshheading:1386162-Oligodeoxyribonucleotides,
pubmed-meshheading:1386162-Oncogene Proteins, Viral,
pubmed-meshheading:1386162-Polymerase Chain Reaction,
pubmed-meshheading:1386162-RNA, Neoplasm,
pubmed-meshheading:1386162-Restriction Mapping,
pubmed-meshheading:1386162-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1386162-Transcription Factors,
pubmed-meshheading:1386162-Translocation, Genetic
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pubmed:year |
1992
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pubmed:articleTitle |
Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia.
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pubmed:affiliation |
Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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