| pubmed-article:1386059 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1386059 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1386059 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:1386059 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1386059 | lifeskim:mentions | umls-concept:C0002131 | lld:lifeskim |
| pubmed-article:1386059 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1386059 | pubmed:dateCreated | 1992-8-25 | lld:pubmed |
| pubmed-article:1386059 | pubmed:abstractText | A panel of seven monoclonal antibodies recognizing human T-cell antigen receptor (TcR) V alpha or V beta subsets has been used to measure TcR gene expression in peripheral blood lymphocytes and mixed lymphocyte culture responses (MLR) between DR2- and DR2+ (DRw15+) donors. There were no significant differences between DR2- and DR2+ donors in per cent T cells in fresh peripheral blood labelled with any of these antibodies, which included an antibody recognizing V beta 8. This indicates strongly that increased negative selection of V beta 8+ T cells does not occur in DR2+ compared with DR2- individuals. In MLR between DR2- and DR2+ donors the only significant change compared with fresh peripheral lymphocytes was that T cells expressing V beta 5.1 were decreased in DR2- lymphocyte populations responding to DR2 alloantigen. No changes in levels of V beta 8+ T cells were detected in MLR between DR2- and DR2+ donors. This suggests that V beta 8+ T cells are not predominantly reactive against DR2 (DRw15). The data support the concept that alloreactivity against a single class II major histocompatibility complex (MHC) mismatch is mediated by T cells expressing a range of different TcR V beta molecules. | lld:pubmed |
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| pubmed-article:1386059 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1386059 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1386059 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1386059 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1386059 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1386059 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:1386059 | pubmed:author | pubmed-author:SellsR ARA | lld:pubmed |
| pubmed-article:1386059 | pubmed:author | pubmed-author:CrosbyII | lld:pubmed |
| pubmed-article:1386059 | pubmed:author | pubmed-author:ChristmasS... | lld:pubmed |
| pubmed-article:1386059 | pubmed:author | pubmed-author:BrewRR | lld:pubmed |
| pubmed-article:1386059 | pubmed:author | pubmed-author:GecimI EIE | lld:pubmed |
| pubmed-article:1386059 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1386059 | pubmed:volume | 76 | lld:pubmed |
| pubmed-article:1386059 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1386059 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1386059 | pubmed:pagination | 192-6 | lld:pubmed |
| pubmed-article:1386059 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1386059 | pubmed:meshHeading | pubmed-meshheading:1386059-... | lld:pubmed |
| pubmed-article:1386059 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1386059 | pubmed:articleTitle | Human T cells expressing V beta 8 do not predominantly recognize DR2 alloantigen. | lld:pubmed |
| pubmed-article:1386059 | pubmed:affiliation | Department of Immunology, University of Liverpool. | lld:pubmed |
| pubmed-article:1386059 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1386059 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1386059 | lld:pubmed |
