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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1992-8-25
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pubmed:abstractText |
A panel of seven monoclonal antibodies recognizing human T-cell antigen receptor (TcR) V alpha or V beta subsets has been used to measure TcR gene expression in peripheral blood lymphocytes and mixed lymphocyte culture responses (MLR) between DR2- and DR2+ (DRw15+) donors. There were no significant differences between DR2- and DR2+ donors in per cent T cells in fresh peripheral blood labelled with any of these antibodies, which included an antibody recognizing V beta 8. This indicates strongly that increased negative selection of V beta 8+ T cells does not occur in DR2+ compared with DR2- individuals. In MLR between DR2- and DR2+ donors the only significant change compared with fresh peripheral lymphocytes was that T cells expressing V beta 5.1 were decreased in DR2- lymphocyte populations responding to DR2 alloantigen. No changes in levels of V beta 8+ T cells were detected in MLR between DR2- and DR2+ donors. This suggests that V beta 8+ T cells are not predominantly reactive against DR2 (DRw15). The data support the concept that alloreactivity against a single class II major histocompatibility complex (MHC) mismatch is mediated by T cells expressing a range of different TcR V beta molecules.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-1672649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-1675173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-1691261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-1706480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-1832875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-1940788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-1940794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-1967299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-1968289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-2148526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-2186745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-2388035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-2401011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-2409198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-2424978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-2479030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-2526642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-2538552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-2783711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-2784357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-3039001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-3043226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-3258650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-3469787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-3471350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-3494522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-3494611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-3860845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-5682942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-5766941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-6202421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1386059-6604124
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
192-6
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1386059-Antibodies, Monoclonal,
pubmed-meshheading:1386059-Cells, Cultured,
pubmed-meshheading:1386059-Gene Expression,
pubmed-meshheading:1386059-HLA-DR2 Antigen,
pubmed-meshheading:1386059-Humans,
pubmed-meshheading:1386059-Isoantigens,
pubmed-meshheading:1386059-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:1386059-Receptors, Antigen, T-Cell,
pubmed-meshheading:1386059-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:1386059-T-Lymphocytes
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pubmed:year |
1992
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pubmed:articleTitle |
Human T cells expressing V beta 8 do not predominantly recognize DR2 alloantigen.
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pubmed:affiliation |
Department of Immunology, University of Liverpool.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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