|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1992-12-22
|
|
pubmed:abstractText |
In the present study, we have investigated the effects of IL-4 on the proliferation and differentiation of leukemic and normal human B cell precursors (BCP). We have demonstrated that IL-4 significantly inhibited spontaneous [3H]thymidine ([3H]-TdR) incorporation by leukemic blasts from some B lineage acute lymphoblastic leukemia (BCP-ALL) patients (8 of 14). Furthermore, IL-4 was found to suppress the spontaneous and factor-dependent (IL-7 and IL-3) proliferation of normal BCP (CD10+ surface [s] IgM- cells) isolated from fetal bone marrow. Maximum growth inhibition of either leukemic or normal BCP was reached at low IL-4 concentrations (10 U/ml), and the effect was specifically neutralized by anti-IL-4 antibody. IL-4 was further found to induce the expression of CD20 antigen on BCP-ALL cells from a number of the cases examined (5 of 8), but in contrast to leukemic cells, IL-4 failed to induce CD20 antigen on normal BCP. Finally, IL-4 was found to induce neither the expression of cytoplasmic mu chain, nor the appearance of sIgM+ cells in cultures of normal or leukemic BCP. Our data indicate that IL-4 has the potential to inhibit cell proliferation in leukemic and normal human B lymphopoiesis but is unable to drive the transition from BCP to mature B cells.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-1374342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-1693296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-1693526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-1697009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-1705282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-1709049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-1718491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-1884023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-1991449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-2141629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-2189505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-2242419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-2302462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-2404523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-2435412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-2460156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-2467703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-2642502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-2643668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-2653368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-2686678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-2783947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-2784411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-2794508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-2837507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-2954597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-3112225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-3151065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-3260035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-3260922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-3262646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-3262709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-3291983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-3317043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-3498944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1385474-3501371
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD20,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Neprilysin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, B-Cell
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0021-9738
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
90
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1697-706
|
|
pubmed:dateRevised |
2010-9-7
|
|
pubmed:meshHeading |
pubmed-meshheading:1385474-Antigens, CD,
pubmed-meshheading:1385474-Antigens, CD20,
pubmed-meshheading:1385474-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:1385474-B-Lymphocytes,
pubmed-meshheading:1385474-Burkitt Lymphoma,
pubmed-meshheading:1385474-Cell Division,
pubmed-meshheading:1385474-Cell Line,
pubmed-meshheading:1385474-DNA Replication,
pubmed-meshheading:1385474-Hematopoietic Stem Cells,
pubmed-meshheading:1385474-Humans,
pubmed-meshheading:1385474-Immunoglobulin M,
pubmed-meshheading:1385474-Interleukin-4,
pubmed-meshheading:1385474-Neprilysin,
pubmed-meshheading:1385474-Receptors, Antigen, B-Cell,
pubmed-meshheading:1385474-Tumor Cells, Cultured
|
|
pubmed:year |
1992
|
|
pubmed:articleTitle |
Interleukin 4 inhibits in vitro proliferation of leukemic and normal human B cell precursors.
|
|
pubmed:affiliation |
Laboratory for Immunological Research, Schering-Plough, Dardilly, France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
