Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
1992-10-30
pubmed:databankReference
pubmed:abstractText
Apurinic/apyrimidinic (AP) sites are pre-mutagenic DNA lesions which occur spontaneously and following exposure of cells to ionising radiation or chemical mutagens. HAP1 (Human AP endonuclease 1), the major enzyme in human cells initiating repair of AP sites, shows strong sequence homology to DNA repair enzymes from bacteria, Drosophila and other mammalian species. We have cloned the HAP1 gene and determined its complete nucleotide sequence. The site of transcription initiation has been mapped to 452 bp upstream of the ATG initiation codon in the genomic DNA. The HAP1 gene consists of five exons and is unusually small (less than 2.6 kb from transcription initiation site to polyadenylation sequence) with 54% of the protein coding region and the entire 3' untranslated region contained within a single exon. The first exon is non-coding. Regions of three exons show sequence homology to the E.coli xth (exonuclease III) gene. Using in situ hybridisation, the HAP1 gene has been localised to human chromosome 14q 11.2-12.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-1091930, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-1697933, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-1708495, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-1713691, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-1719477, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-1722334, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-1939131, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-2062644, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-2430946, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-2440339, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-2461302, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-2468646, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-2850170, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-2943217, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-3003798, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-3034813, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-3049539, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-3307585, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-4626532, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-6287922, http://linkedlifedata.com/resource/pubmed/commentcorrection/1383925-6791577
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0305-1048
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
20
pubmed:geneSymbol
HAP1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4417-21
pubmed:dateRevised
2010-9-7
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Structure of the human DNA repair gene HAP1 and its localisation to chromosome 14q 11.2-12.
pubmed:affiliation
Imperial Cancer Research Fund, Oxford, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't