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pubmed-article:1383027pubmed:abstractTextThe developmental expression of voltage-sensitive K+ channels was analyzed by Northern blot in mouse skeletal muscle. Of nine Shaker-like genes studied, eight are expressed in this mammalian muscle. Their expression is differentially regulated during development. The mouse cell line C2C12 has been used to study expression of voltage-sensitive K+ channels during in vitro myotube differentiation. Different voltage-sensitive K+ channel messages are also expressed in these cells which display a pattern of expression depending upon the differentiation stage. The message for the very peculiar K+ channel of IsK type could only be detected by polymerase chain reaction on skeletal muscle mRNA.lld:pubmed
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pubmed-article:1383027pubmed:articleTitleDevelopmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells.lld:pubmed
pubmed-article:1383027pubmed:affiliationInstitut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France.lld:pubmed
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