|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8-9
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|
pubmed:dateCreated |
1992-10-8
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|
pubmed:abstractText |
Chemotherapy is the mainstay of therapy for patients with non-Hodgkin lymphoma. Among side-effects associated with the use of chemotherapy, immunosuppression is one which can be potentially fatal. In hepatitis B carriers, immunosuppression permits widespread infection of the hepatocytes and its subsequent withdrawal causes an "immunological rebound" leading to massive necrosis of hepatocytes. 4 patients who died of fulminant hepatitis following chemotherapy are reported. These were patients with positive hepatitis B serology. Caution is advised when treating non-Hodgkin lymphoma in patients from hepatitis B endemic regions.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0959-8049
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
28A
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1338-9
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|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:1381211-Adult,
pubmed-meshheading:1381211-Aged,
pubmed-meshheading:1381211-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:1381211-Bleomycin,
pubmed-meshheading:1381211-Cyclophosphamide,
pubmed-meshheading:1381211-Doxorubicin,
pubmed-meshheading:1381211-Drug-Induced Liver Injury,
pubmed-meshheading:1381211-Female,
pubmed-meshheading:1381211-Hepatitis B,
pubmed-meshheading:1381211-Humans,
pubmed-meshheading:1381211-Immunocompromised Host,
pubmed-meshheading:1381211-Liver Diseases,
pubmed-meshheading:1381211-Lymphoma, Non-Hodgkin,
pubmed-meshheading:1381211-Male,
pubmed-meshheading:1381211-Methotrexate,
pubmed-meshheading:1381211-Middle Aged,
pubmed-meshheading:1381211-Prednisolone,
pubmed-meshheading:1381211-Prednisone,
pubmed-meshheading:1381211-Vincristine
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|
pubmed:year |
1992
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|
pubmed:articleTitle |
Fulminant hepatic failure in non-Hodgkin lymphoma patients treated with chemotherapy.
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|
pubmed:affiliation |
Department of Medical Oncology, Singapore General Hospital.
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|
pubmed:publicationType |
Journal Article,
Case Reports
|
