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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
4
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pubmed:dateCreated |
1992-9-8
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pubmed:abstractText |
Tumor stroma is characterized by the development of new blood vessels, an inflammatory cell infiltration, and a fibrotic reaction. The inflammatory component of tumor stroma plays an important role in the modulation of tumor expansion. In this respect, macrophages constitute a major part of the inflammatory cell infiltration and can exert cytotoxic activity against tumor cells. The accumulation of macrophages in the vicinity of the tumor suggests their recruitment from circulating blood monocytes through the local release of chemotactic factors for monocytes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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|
pubmed:issn |
0008-543X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
70
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
854-60
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:1379511-Adenocarcinoma,
pubmed-meshheading:1379511-Aged,
pubmed-meshheading:1379511-Biopsy,
pubmed-meshheading:1379511-Carcinoma, Small Cell,
pubmed-meshheading:1379511-Chemokine CCL2,
pubmed-meshheading:1379511-Chemotactic Factors,
pubmed-meshheading:1379511-Chemotaxis,
pubmed-meshheading:1379511-Eosine Yellowish-(YS),
pubmed-meshheading:1379511-Female,
pubmed-meshheading:1379511-Hematoxylin,
pubmed-meshheading:1379511-Humans,
pubmed-meshheading:1379511-Inflammation,
pubmed-meshheading:1379511-Lung Neoplasms,
pubmed-meshheading:1379511-Macrophages,
pubmed-meshheading:1379511-Male,
pubmed-meshheading:1379511-Mesothelioma,
pubmed-meshheading:1379511-Middle Aged,
pubmed-meshheading:1379511-Pleural Effusion,
pubmed-meshheading:1379511-Pleural Effusion, Malignant,
pubmed-meshheading:1379511-Tumor Cells, Cultured
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pubmed:year |
1992
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pubmed:articleTitle |
Mechanism for the recruitment of macrophages to cancer site. In vivo concentration gradient of monocyte chemotactic activity.
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pubmed:affiliation |
Inserm U14, Vandoeuvre-lès-Nancy, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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