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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
1992-8-18
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pubmed:abstractText |
CD40 is a B-cell surface molecule that has been shown to induce B-cell growth upon ligation with monoclonal antibodies. This report shows that triggering via CD40 is essential for the activation of resting B cells by helper T cells (Th). A soluble fusion protein of CD40 and human immunoglobulin, CD40-Ig, inhibited the induction of B-cell cycle entry, proliferation, and differentiation by activated Th1 and Th2. The ligand for CD40 was identified as a 39-kDa membrane protein that was selectively expressed on activated Th. A monoclonal antibody specific for the 39-kDa protein inhibited CD40-Ig binding and also inhibited the activation of B cells by Th. These data indicate that the 39-kDa membrane protein expressed on activated Th is a binding protein for CD40 and functions to transduce the signal for Th-dependent B-cell activation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-1694723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-1701779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-1701824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-1702555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-1704029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-1705282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-1706378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-1706382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-1708162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-1711085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-1713678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-1716631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-1910693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-2144543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-2445658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-2467936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-2475341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-2476481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-2476483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-2571505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-2950524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-2960773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-2963333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-3489040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-6184304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-6195255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-6208128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1378631-6802927
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6550-4
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1378631-Animals,
pubmed-meshheading:1378631-Antibodies, Monoclonal,
pubmed-meshheading:1378631-Antibody Formation,
pubmed-meshheading:1378631-Antigens, CD,
pubmed-meshheading:1378631-Antigens, CD40,
pubmed-meshheading:1378631-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:1378631-Antigens, Surface,
pubmed-meshheading:1378631-B-Lymphocytes,
pubmed-meshheading:1378631-Cell Cycle,
pubmed-meshheading:1378631-Cell Differentiation,
pubmed-meshheading:1378631-Lymphocyte Activation,
pubmed-meshheading:1378631-Lymphocyte Cooperation,
pubmed-meshheading:1378631-Membrane Proteins,
pubmed-meshheading:1378631-Mice,
pubmed-meshheading:1378631-Mice, Inbred DBA,
pubmed-meshheading:1378631-Protein Binding,
pubmed-meshheading:1378631-Signal Transduction,
pubmed-meshheading:1378631-T-Lymphocytes, Helper-Inducer
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pubmed:year |
1992
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pubmed:articleTitle |
A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.
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pubmed:affiliation |
Department of Micribiology, Dartmouth Medical School, Lebanon, NH 03756.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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