Linked Life Data

1376219

Source:http://linkedlifedata.com/resource/pubmed/id/1376219

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-7-10
pubmed:abstractText
Monoclonal antibodies were prepared by using the anterior horn region of human embryonic spinal cord as immunogen. To increase the specificity of the immune response towards the anterior horn cells, mice were first injected with antigens from the posterior horn and then immunosuppressed with cyclophosphamide; subsequently antigens from the anterior horn were injected. One of the monoclonal antibodies recognizes a small population of anterior horn cells of human embryonic spinal cord during a transient period of development (9-10th embryonic week); these cells are probably motoneurons according to their location in the spinal cord, their positive staining for acetylcholinesterase and their large nuclei. The staining pattern has a special axial distribution as it is limited to the cervical and thoracic regions of the spinal cord. The antibody is species-specific and shows a high degree of tissue specificity. Since this antibody distinguishes a small group of anterior horn cells in the spinal cord during a specific developmental stage, it opens stimulating perspectives for further investigation on the nature of the antigen and its putative role during the development of the human embryonic spinal cord.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0165-3806
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
109-17
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
A monoclonal antibody distinguishes anterior horn cells of human embryonic spinal cord during a transient period of development.
pubmed:affiliation
Division of Clinical Neurophysiology, Centre Médical Universitaire, Geneva, Switzerland.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't