| pubmed-article:1375250 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1375250 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:1375250 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1375250 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1375250 | lifeskim:mentions | umls-concept:C0282580 | lld:lifeskim |
| pubmed-article:1375250 | lifeskim:mentions | umls-concept:C0017350 | lld:lifeskim |
| pubmed-article:1375250 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:1375250 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:1375250 | lifeskim:mentions | umls-concept:C0206243 | lld:lifeskim |
| pubmed-article:1375250 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:1375250 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:1375250 | pubmed:dateCreated | 1992-6-25 | lld:pubmed |
| pubmed-article:1375250 | pubmed:abstractText | The epitope corresponding to amino acid residues 147-161 of the nucleoprotein (NP) of influenza A virus is recognized by CTL in association with H-2Kd class I Ag. Herein, we engineered an Ig molecule carrying this CTL epitope by replacing the diversity gene segment of the H chain V region of an anti-arsonate antibody with an oligonucleotide that encodes the CTL epitope. The chimeric H chain gene was expressed either alone or together with the parental L chain in the nonsecreting BALB/c myeloma B cell line, SP2/0. The Ig produced by cells transfected with both the chimeric H chain and parental L chains genes expressed the NP epitope but lost the original arsonate binding activity. In addition, SP2/0 cells expressing the chimeric H chain either alone or together with the parental L chain were lysed by class I restricted NP-epitope specific CTL. By contrast, SP2/0 cells pulsed with soluble chimeric Ig molecules were not lysed by the specific CTL. These observations indicate that: 1) this particular CTL epitope can be expressed on Ig molecules without altering the H and L chain pairing; 2) this CTL epitope can be generated from this chimeric Ig in which it is surrounded by flanking regions distinct from those of the viral NP; and 3) the generation of this CTL epitope from the Ig molecule requires the endogenous pathway as do viral proteins. | lld:pubmed |
| pubmed-article:1375250 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1375250 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1375250 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1375250 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1375250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1375250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1375250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1375250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1375250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1375250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1375250 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1375250 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1375250 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1375250 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1375250 | pubmed:author | pubmed-author:SchulmanJJ | lld:pubmed |
| pubmed-article:1375250 | pubmed:author | pubmed-author:BonaCC | lld:pubmed |
| pubmed-article:1375250 | pubmed:author | pubmed-author:ShahHH | lld:pubmed |
| pubmed-article:1375250 | pubmed:author | pubmed-author:MoranTT | lld:pubmed |
| pubmed-article:1375250 | pubmed:author | pubmed-author:KrystalMM | lld:pubmed |
| pubmed-article:1375250 | pubmed:author | pubmed-author:KuzuYY | lld:pubmed |
| pubmed-article:1375250 | pubmed:author | pubmed-author:ZaghouaniHH | lld:pubmed |
| pubmed-article:1375250 | pubmed:author | pubmed-author:KuzuHH | lld:pubmed |
| pubmed-article:1375250 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1375250 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1375250 | pubmed:volume | 148 | lld:pubmed |
| pubmed-article:1375250 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1375250 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1375250 | pubmed:pagination | 3604-9 | lld:pubmed |
| pubmed-article:1375250 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1375250 | pubmed:meshHeading | pubmed-meshheading:1375250-... | lld:pubmed |
| pubmed-article:1375250 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1375250 | pubmed:articleTitle | Cells expressing an H chain Ig gene carrying a viral T cell epitope are lysed by specific cytolytic T cells. | lld:pubmed |
| pubmed-article:1375250 | pubmed:affiliation | Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029. | lld:pubmed |
| pubmed-article:1375250 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1375250 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1375250 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1375250 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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