Linked Life Data

1372380

Source:http://linkedlifedata.com/resource/pubmed/id/1372380

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1992-4-23
pubmed:abstractText
The source of the membranous materials that accumulate in distal axons of rats intoxicated with p-bromophenylacetylurea (BPAU) was studied by electron microscopy. 35S-Methionine was injected into the ventral horn of the spinal cord at 2, 14, and 35 days after injection of BPAU. Three days later, samples of the deep peroneal nerves were obtained, and autoradiographs of thin cross sections were prepared. Organellar accumulations were absent from vehicle-treated control nerves and rare in the clinically latent period after administration of BPAU. In later stages of neuropathy, approximately 20% of the myelinated axons in any specific section were swollen and packed with tubules, membranes, and mitochondria. Numerous silver grains were located over the accumulated organelles, and the coincidence was statistically significant. The results indicate a sporadic local stasis of fast-transported proteins and provide a plausible explanation for axonal damage in BPAU neuropathy.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0025-6196
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
341-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Tubulomembranous lesions in p-bromophenylacetylurea neuropathy reflect local stasis of fast axonal transport: evidence from electron microscopic autoradiography.
pubmed:affiliation
Department of Pharmacology, Mayo Clinic, Rochester, MN 55905.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.