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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1992-2-27
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pubmed:abstractText |
Despite their different pathogeneses, allergic and irritant contact dermatitis show a remarkable similarity with respect to clinical appearance, histology, and immunohistology. To further analyze this apparent contradiction, our study was designed to meticulously compare cellular infiltrates in irritant and allergic patch-test reactions by immunostaining with a broad panel of monoclonal antibodies. For this purpose, skin biopsies from allergic and irritant patch-test reactions of similar inflammatory degree were obtained from the same probands. We found that after 72 h both types of reaction were characterized by an identical dermal infiltrate consisting mainly of memory T cells, many of which were activated, and macrophages. Dermal and epidermal Langerhans cell density and HLA--DR expression of keratinocytes were also virtually identical. Our results show that antigen recognition by specific memory T cells as well as irritants can finally induce the same pattern of inflammation, including activation of T cells obviously independent of exogenous antigen.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD1,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD2,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD5,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-202X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
166-70
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1370676-Adult,
pubmed-meshheading:1370676-Aged,
pubmed-meshheading:1370676-Antigens, CD,
pubmed-meshheading:1370676-Antigens, CD1,
pubmed-meshheading:1370676-Antigens, CD2,
pubmed-meshheading:1370676-Antigens, CD3,
pubmed-meshheading:1370676-Antigens, CD4,
pubmed-meshheading:1370676-Antigens, CD5,
pubmed-meshheading:1370676-Antigens, CD8,
pubmed-meshheading:1370676-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1370676-Cell Count,
pubmed-meshheading:1370676-Dermatitis, Atopic,
pubmed-meshheading:1370676-Dermatitis, Contact,
pubmed-meshheading:1370676-Female,
pubmed-meshheading:1370676-Humans,
pubmed-meshheading:1370676-Langerhans Cells,
pubmed-meshheading:1370676-Male,
pubmed-meshheading:1370676-Middle Aged,
pubmed-meshheading:1370676-Receptors, Antigen, T-Cell,
pubmed-meshheading:1370676-Receptors, Immunologic,
pubmed-meshheading:1370676-Skin Tests,
pubmed-meshheading:1370676-T-Lymphocytes
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pubmed:year |
1992
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pubmed:articleTitle |
Common pathogenetic pathways in allergic and irritant contact dermatitis.
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pubmed:affiliation |
Department of Dermatology, University of Kiel, FRG.
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pubmed:publicationType |
Journal Article
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