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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1992-2-19
|
| pubmed:abstractText |
To assist in identifying factors that determine the clinical outcome of cow milk allergy, we subjected to rechallenge 37 patients with a history of cow milk allergy, mean (+/- SD) age 27.6 +/- 7.1 months, after a follow-up of 13.5 +/- 5.1 months with a milk-free diet. A solid-phase enzyme-linked immunoassay was used to assess the total number of immunoglobulin-secreting and specific antibody-secreting cells among peripheral blood lymphocytes primed during provocation by milk antigens, giving indirect evidence of local immune response in the gut. Patients with persistent cow milk allergy (n = 13) had milder reactions at rechallenge than they had shown at the time of diagnosis. Numbers of immunoglobulin-secreting cells in these patients increased significantly from a geometric mean (95% confidence interval) in the IgA class of 1570 (1009, 2445) to 2984 (1941, 4583) IgA-secreting cells/10(6) cells, in the IgG class of 1445 (1067, 1959) to 2740 (1698, 4425) IgG-secreting cells/10(6) cells, and in the IgM class of 842 (534, 1325) to 2235 (1429, 3495) IgM-secreting cells/10(6) cells. By contrast, in patients (n = 24) who had acquired cow milk tolerance, the number of immunoglobulin-secreting cells did not increase during provocation. The total number of IgA-secreting cells before rechallenge was significantly higher than it had been before the initial challenge. The patients who acquired cow milk tolerance also had specific antibody-secreting cells of IgA isotype before the second challenge. These results indicate that in cow milk allergy the ability to mount a local immune response against cow milk antigens, particularly in the IgA class, is related to the suppression of clinical sensitivity.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Caseins,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Lactalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/Lactoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Albumin, Bovine
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0022-3476
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
120
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
9-15
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:1370536-Animals,
pubmed-meshheading:1370536-Antibodies,
pubmed-meshheading:1370536-Antibody-Producing Cells,
pubmed-meshheading:1370536-Caseins,
pubmed-meshheading:1370536-Child, Preschool,
pubmed-meshheading:1370536-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:1370536-Epitopes,
pubmed-meshheading:1370536-Follow-Up Studies,
pubmed-meshheading:1370536-Humans,
pubmed-meshheading:1370536-Immune Tolerance,
pubmed-meshheading:1370536-Immunoglobulin A,
pubmed-meshheading:1370536-Immunoglobulin G,
pubmed-meshheading:1370536-Immunoglobulin M,
pubmed-meshheading:1370536-Infant,
pubmed-meshheading:1370536-Lactalbumin,
pubmed-meshheading:1370536-Lactoglobulins,
pubmed-meshheading:1370536-Milk,
pubmed-meshheading:1370536-Milk Hypersensitivity,
pubmed-meshheading:1370536-Serum Albumin, Bovine
|
| pubmed:year |
1992
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| pubmed:articleTitle |
Local immune response in patients with cow milk allergy: follow-up of patients retaining allergy or becoming tolerant.
|
| pubmed:affiliation |
Department of Pediatrics, University of Tampere, Finland.
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| pubmed:publicationType |
Journal Article
|