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rdf:type |
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lifeskim:mentions |
|
|
pubmed:issue |
3
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pubmed:dateCreated |
1991-6-27
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|
pubmed:abstractText |
It has been suggested that peptide inhibitors of prolyl endopeptidase (PEP) may act as anti-amnestic agents. In the hope of finding PEP inhibitors in milk proteins, we synthesized a total of 37 human beta-casein peptide fragments containing proline residues. It was found that the peptides with PEP inhibition activity in vitro were located in the region of amino acid residues 49-59 of human beta-casein. The most potent inhibitor was Ile-Tyr-Pro-Phe-Val-Glu-Pro-Ile (IC50 = 8 microM).
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
B
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0002-1369
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
55
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
825-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
|
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pubmed:year |
1991
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pubmed:articleTitle |
Inhibition of prolyl endopeptidase by synthetic peptide fragments of human beta-casein.
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|
pubmed:affiliation |
Central Research Laboratories, Ajinomoto Co., Inc., Kawasaki, Japan.
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pubmed:publicationType |
Journal Article
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